Tailoring the Physicochemical Properties of Antimicrobial Peptides onto Thiazole-based γ-Peptide Foldamer.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c00077
Abstract: Antimicrobial peptides (AMPs) are amphipathic molecules displaying broad-spectrum bactericidal activity providing opportunities to develop new generation of antibiotics. However their use is limited either by poor metabolic stability or high hemolytic activity. We herein addressed… read more here.
Keywords: physicochemical properties; thiazole based; tailoring physicochemical; based peptide ... See more keywords
Gemcitabine Based Peptide Conjugate with Improved Metabolic Properties and Dual Mode of Efficacy.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.6b00961
Abstract: Gemcitabine is a clinically established anticancer agent potent in various solid tumors but limited by its rapid metabolic inactivation and off-target toxicity. We have previously generated a metabolically superior to gemcitabine molecule (GSG) by conjugating… read more here.
Keywords: gemcitabine; gsg; gemcitabine based; peptide conjugate ... See more keywords
Predicting the Success of Fmoc-Based Peptide Synthesis
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c02425
Abstract: Synthetic peptides are commonly used in biomedical science for many applications in basic and translational research. While peptide synthesis is generally easy and reliable, the chemical nature of some amino acids as well as the… read more here.
Keywords: predicting success; synthesis; success fmoc; peptide synthesis ... See more keywords
Logic Circuits Based on 2A Peptide Sequences in the Yeast Saccharomyces cerevisiae.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.2c00506
Abstract: Gene digital circuits are the subject of many studies in Synthetic Biology due to their various applications from pollutant detection to medical diagnostics and biocomputing. Complex logic functions are calculated via small genetic components that… read more here.
Keywords: saccharomyces cerevisiae; yeast saccharomyces; peptide sequences; based peptide ... See more keywords
Photoelectric conversion based on peptide–porphyrin conjugates assembled hydrogel
Sign Up to like & getrecommendations! Published in 2021 at "New Journal of Chemistry"
DOI: 10.1039/d1nj00573a
Abstract: Peptide–porphyrin conjugates facilitated porphyrin to participate in the assembly of hydrogel, improving the utilization of porphyrin and photoelectric conversion efficiency. read more here.
Keywords: peptide porphyrin; conversion based; based peptide; porphyrin conjugates ... See more keywords
In silico analysis for development of epitopes-based peptide vaccine against Alkhurma hemorrhagic fever virus
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2019.1651673
Abstract: Abstract Alkhurma hemorrhagic fever virus (ALKV) causes a fatal clinical disease in human beings of different tropical and sub-tropical regions. Recently, the ALKV epidemics have raised a great public health concern with the room for… read more here.
Keywords: hemorrhagic fever; fever virus; peptide vaccine; based peptide ... See more keywords
Antibody characterization using novel ERLIC-MS/MS-based peptide mapping
Sign Up to like & getrecommendations! Published in 2018 at "mAbs"
DOI: 10.1080/19420862.2018.1505179
Abstract: ABSTRACT Electrostatic repulsion hydrophilic interaction chromatography (ERLIC) coupled with mass spectrometry (MS) is a technique that is increasingly being used as a trapping/enrichment tool for glycopeptides/phosphorylated peptides or sample fractionation in proteomics research. Here, we… read more here.
Keywords: novel erlic; method; erlic based; based peptide ... See more keywords
Epitope-based peptide vaccine design and elucidation of novel compounds against 3C like protein of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0264700
Abstract: Coronaviruses (CoVs) are positive-stranded RNA viruses with short clubs on their edges. CoVs are pathogenic viruses that infect several animals and plant organisms, as well as humans (lethal respiratory dysfunctions). A noval strain of CoV… read more here.
Keywords: epitope based; sars cov; based peptide; like protein ... See more keywords