Sequence and structure-based peptides as potent amyloid inhibitors: A review.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2020.108614
Abstract: Misfolded and natively disordered globular proteins tend to aggregate together in an interwoven fashion to form fibrous, proteinaceous deposits referred to as amyloid fibrils. Formation and deposition of such insoluble fibrils are the characteristic features… read more here.
Keywords: peptides potent; structure based; sequence structure; structure ... See more keywords
Receptor-Based Peptides for Inhibition of Leukotoxin Activity.
Sign Up to like & getrecommendations! Published in 2018 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.7b00230
Abstract: The Gram-negative bacterium Aggregatibacter actinomycetemcomitans, commonly associated with localized aggressive periodontitis (LAP), secretes an RTX (repeats-in-toxin) protein leukotoxin (LtxA) that targets human white blood cells, an interaction that is driven by its recognition of the… read more here.
Keywords: receptor based; inhibit ltxa; peptides inhibition; activity ... See more keywords
Synthesis of temporin L hydroxamate-based peptides and evaluation of their coordination properties with iron(III ).
Sign Up to like & getrecommendations! Published in 2023 at "Dalton transactions"
DOI: 10.1039/d2dt04099a
Abstract: Ferric iron is an essential nutrient for bacterial growth. Pathogenic bacteria synthesize iron-chelating entities known as siderophores to sequestrate ferric iron from host organisms in order to colonize and replicate. The development of antimicrobial peptides… read more here.
Keywords: hydroxamate based; based peptides; spectroscopy; iron ... See more keywords