PEGylation Regulates Self‐Assembled Small‐Molecule Dye–Based Probes from Single Molecule to Nanoparticle Size for Multifunctional NIR‐II Bioimaging
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.201800973
Abstract: To date, small-molecule dye-based probes have been at the forefront of research in biomedical imaging, especially in the second near-infrared (NIR-II) window (1.0-1.7 µm). However, how to precisely regulate the synthesized size of NIR-II organic… read more here.
Keywords: molecule; dye based; nir; size ... See more keywords
Targeting Peptide-Based Probes for Molecular Imaging and Diagnosis.
Sign Up to like & getrecommendations! Published in 2018 at "Advanced materials"
DOI: 10.1002/adma.201804827
Abstract: A series of novel peptide-based molecular probes for different biomarkers is highlighted herein. These probes can provide targeted recognition with high affinity, high specificity, high penetration, and rapid excretion ability. These sensitive peptides can achieve… read more here.
Keywords: targeting peptide; diagnosis; probes molecular; peptide based ... See more keywords
Proteome‐Wide Identification of On‐ and Off‐Targets of Bcl‐2 Inhibitors in Native Biological Systems by Using Affinity‐Based Probes (AfBPs)
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201800380
Abstract: Selective inhibition of proteins of the Bcl‐2 family by small‐molecule inhibitors is a promising new approach in drug discovery. However, information about how these molecules interact with their cellular targets (on‐ and off‐) is highly… read more here.
Keywords: probes afbps; targets bcl; bcl inhibitors; affinity based ... See more keywords
Tagged Benzoxazin‐4‐Ones as Novel Activity‐Based Probes for Serine Proteases
Sign Up to like & getrecommendations! Published in 2021 at "ChemBioChem"
DOI: 10.1002/cbic.202000848
Abstract: Activity‐based probes (ABPs) are valuable chemical tools for profiling enzymes. They have been particularly useful in the study of proteases. ABPs rely on electrophilic scaffolds that covalently modify the target enzymes. Ideally, they can be… read more here.
Keywords: serine proteases; tagged benzoxazin; benzoxazin ones; activity based ... See more keywords
Internal Ubiquitin Electrophiles for Covalent Trapping and Inhibition of Deubiquitinases
Sign Up to like & getrecommendations! Published in 2025 at "Chembiochem"
DOI: 10.1002/cbic.202500318
Abstract: The ubiquitin (Ub) system governs vital cellular processes in eukaryotic biology through an intricate network of Ub–protein interactions. While semisynthetic C‐terminal Ub electrophiles (UbEs) are widely used to study Ub transfer and deubiquitinase (Dub) activity,… read more here.
Keywords: covalent trapping; electrophiles covalent; site; ubiquitin electrophiles ... See more keywords
A versatile small-molecule fluorescence scaffold: Carbazole derivatives for bioimaging
Sign Up to like & getrecommendations! Published in 2020 at "Coordination Chemistry Reviews"
DOI: 10.1016/j.ccr.2020.213257
Abstract: Abstract Carbazole derivatives have been receiving extensive attention owing to the merits of favorable donor ability, good planarity, rich photophysical properties, and excellent biocompatibility. In recent years, carbazole-based small molecular fluorescent probes have developed rapidly… read more here.
Keywords: fluorescence; carbazole based; carbazole derivatives; derivatives bioimaging ... See more keywords
Decoding the Penicillin-Binding Proteins with Activity-Based Probes.
Sign Up to like & getrecommendations! Published in 2025 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.5c00113
Abstract: ConspectusThe bacterial cell wall is a complex structure that is primarily composed of peptidoglycan (PG), which provides protection from the environment and structural rigidity for the cell. As such, PG plays an important role in… read more here.
Keywords: penicillin binding; binding proteins; cell; activity based ... See more keywords
Fluorescence Light-Up of G4 DNA Structures Using Azlactone-Based Probes.
Sign Up to like & getrecommendations! Published in 2025 at "Biochemistry"
DOI: 10.1021/acs.biochem.5c00280
Abstract: G-rich sequences of DNA and RNA can form G-quadruplex (G4) structures, modulating a myriad of biological processes. Thus, it is imperative to understand the structural topologies, location, and function of G4s under cell-free conditions and… read more here.
Keywords: light dna; based probes; azlactone based; fluorescence light ... See more keywords
18F-/68Ga-Labeled Peptide-Based Probes for PET Imaging of ROR1 Expression.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5c02016
Abstract: Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is highly upregulated in multiple cancers and serves as a promising biomarker for patient staging and therapy guidance. We designed five ROR1-targeted radiotracers, including linear and cyclic peptides… read more here.
Keywords: peptide based; 68ga labeled; 18f 68ga; labeled peptide ... See more keywords
Facile Preparation of UFMylation Activity-Based Probes by Chemoselective Installation of Electrophiles at the C-Terminus of Recombinant UFM1
Sign Up to like & getrecommendations! Published in 2022 at "ACS Central Science"
DOI: 10.1021/acscentsci.2c00203
Abstract: Aberrations in protein modification with ubiquitin-fold modifier (UFM1) are associated with a range of diseases, but the biological function and regulation of this post-translational modification, known as UFMylation, remain enigmatic. To provide activity-based probes for… read more here.
Keywords: terminus recombinant; based probes; ufmylation; activity based ... See more keywords
Activity-based probes for the high temperature requirement A serine proteases.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical biology"
DOI: 10.1021/acschembio.0c00279
Abstract: The high temperature requirement A (HTRA) family of serine proteases mediates protein quality control. These proteins process misfolded proteins in several diseases including Alzheimer's disease (AD) and Parkinson's disease (PD). While their structures and activation… read more here.
Keywords: serine proteases; based probes; high temperature; activity based ... See more keywords