PEGylation Regulates Self‐Assembled Small‐Molecule Dye–Based Probes from Single Molecule to Nanoparticle Size for Multifunctional NIR‐II Bioimaging
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.201800973
Abstract: To date, small-molecule dye-based probes have been at the forefront of research in biomedical imaging, especially in the second near-infrared (NIR-II) window (1.0-1.7 µm). However, how to precisely regulate the synthesized size of NIR-II organic… read more here.
Keywords: molecule; dye based; nir; size ... See more keywords
Targeting Peptide-Based Probes for Molecular Imaging and Diagnosis.
Sign Up to like & getrecommendations! Published in 2018 at "Advanced materials"
DOI: 10.1002/adma.201804827
Abstract: A series of novel peptide-based molecular probes for different biomarkers is highlighted herein. These probes can provide targeted recognition with high affinity, high specificity, high penetration, and rapid excretion ability. These sensitive peptides can achieve… read more here.
Keywords: targeting peptide; diagnosis; probes molecular; peptide based ... See more keywords
Proteome‐Wide Identification of On‐ and Off‐Targets of Bcl‐2 Inhibitors in Native Biological Systems by Using Affinity‐Based Probes (AfBPs)
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201800380
Abstract: Selective inhibition of proteins of the Bcl‐2 family by small‐molecule inhibitors is a promising new approach in drug discovery. However, information about how these molecules interact with their cellular targets (on‐ and off‐) is highly… read more here.
Keywords: probes afbps; targets bcl; bcl inhibitors; affinity based ... See more keywords
Tagged Benzoxazin‐4‐Ones as Novel Activity‐Based Probes for Serine Proteases
Sign Up to like & getrecommendations! Published in 2021 at "ChemBioChem"
DOI: 10.1002/cbic.202000848
Abstract: Activity‐based probes (ABPs) are valuable chemical tools for profiling enzymes. They have been particularly useful in the study of proteases. ABPs rely on electrophilic scaffolds that covalently modify the target enzymes. Ideally, they can be… read more here.
Keywords: serine proteases; tagged benzoxazin; benzoxazin ones; activity based ... See more keywords
A versatile small-molecule fluorescence scaffold: Carbazole derivatives for bioimaging
Sign Up to like & getrecommendations! Published in 2020 at "Coordination Chemistry Reviews"
DOI: 10.1016/j.ccr.2020.213257
Abstract: Abstract Carbazole derivatives have been receiving extensive attention owing to the merits of favorable donor ability, good planarity, rich photophysical properties, and excellent biocompatibility. In recent years, carbazole-based small molecular fluorescent probes have developed rapidly… read more here.
Keywords: fluorescence; carbazole based; carbazole derivatives; derivatives bioimaging ... See more keywords
Facile Preparation of UFMylation Activity-Based Probes by Chemoselective Installation of Electrophiles at the C-Terminus of Recombinant UFM1
Sign Up to like & getrecommendations! Published in 2022 at "ACS Central Science"
DOI: 10.1021/acscentsci.2c00203
Abstract: Aberrations in protein modification with ubiquitin-fold modifier (UFM1) are associated with a range of diseases, but the biological function and regulation of this post-translational modification, known as UFMylation, remain enigmatic. To provide activity-based probes for… read more here.
Keywords: terminus recombinant; based probes; ufmylation; activity based ... See more keywords
Activity-based probes for the high temperature requirement A serine proteases.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical biology"
DOI: 10.1021/acschembio.0c00279
Abstract: The high temperature requirement A (HTRA) family of serine proteases mediates protein quality control. These proteins process misfolded proteins in several diseases including Alzheimer's disease (AD) and Parkinson's disease (PD). While their structures and activation… read more here.
Keywords: serine proteases; based probes; high temperature; activity based ... See more keywords
Combinatorial Optimization of Activity-Based Probes for Acyl Protein Thioesterases 1 and 2.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00174
Abstract: Acyl protein thioesterases hydrolyze fatty acid thioesters on cysteine residues of proteins. The two protein depalmitoylases APT1 and APT2 have a very high degree of similarity and show substantial overlap in substrate utility. Potent, selective,… read more here.
Keywords: based probes; activity based; acyl protein; protein thioesterases ... See more keywords
Multiplexed probing of proteolytic enzymes using mass cytometry-compatible activity-based probes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c06762
Abstract: The subset of the proteome that contains enzymes in their catalytically active form can be interrogated by using probes tar-geted towards individual specific enzymes. A subset of such enzymes are proteases that are frequently studied… read more here.
Keywords: mass cytometry; activity based; mass; activity ... See more keywords
SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging
Sign Up to like & getrecommendations! Published in 2020 at "Nature Chemical Biology"
DOI: 10.1038/s41589-020-00689-z
Abstract: In December 2019, the first cases of infection with a novel coronavirus, SARS-CoV-2, were diagnosed. Currently, there is no effective antiviral treatment for COVID-19. To address this emerging problem, we focused on the SARS-CoV-2 main… read more here.
Keywords: activity based; cov main; cov mpro; sars cov ... See more keywords
Mechanistic Insights into the Cholesterol-dependent Binding of Perfringolysin O-based Probes and Cell Membranes
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-14002-x
Abstract: Cholesterol distribution in the cell is maintained by both vesicular and non-vesicular sterol transport. Non-vesicular transport is mediated by the interaction of membrane-embedded cholesterol and water-soluble proteins. Small changes to the lipid composition of the… read more here.
Keywords: cholesterol content; perfringolysin; cholesterol; cholesterol dependent ... See more keywords