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   Articles with "based prodrugs" as a keyword



Cannabidiol-Based Prodrugs: Synthesis and Bioevaluation.

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recommendations! Published in 2024 at "ACS medicinal chemistry letters"

DOI: 10.1021/acsmedchemlett.3c00461

Abstract: Cannabidiol (CBD 1) is a nonpsychotic cannabinoid-based drug approved by the U.S. FDA for treating refractory epilepsy, namely, Lennox-Gastaut and Dravet syndrome. However, its low aqueous solubility and oral bioavailability are compensated by administering high… read more here.

Keywords: synthesis bioevaluation; cannabidiol based; cbd based; based prodrugs ... See more keywords

Amplifying the efficacy of ALA-based prodrugs for photodynamic therapy using nanotechnology

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recommendations! Published in 2023 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2023.1137707

Abstract: 5-aminolevulinic acid (ALA) is a clinically approved prodrug involved in intracellular Heme biosynthesis to produce the natural photosensitizer (PS) Protoporphyrin IX (PpIX). ALA based photodynamic therapy (PDT) has been used to treat various malignant and… read more here.

Keywords: nanotechnology; ala based; using nanotechnology; photodynamic therapy ... See more keywords

Molecular Modeling-Guided Design of Phospholipid-Based Prodrugs

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recommendations! Published in 2019 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms20092210

Abstract: The lipidic prodrug approach is an emerging field for improving a number of biopharmaceutical and drug delivery aspects. Owing to their structure and nature, phospholipid (PL)-based prodrugs may join endogenous lipid processing pathways, and hence… read more here.

Keywords: based prodrugs; molecular modeling; drug; phospholipid based ... See more keywords

Prospects and Challenges of Phospholipid-Based Prodrugs

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recommendations! Published in 2018 at "Pharmaceutics"

DOI: 10.3390/pharmaceutics10040210

Abstract: Nowadays, the prodrug approach is used already at the early stages of drug development. Lipidic prodrug approach is a growing field for improving a number of drug properties/delivery/therapy aspects, and can offer solutions for various… read more here.

Keywords: based prodrugs; prospects challenges; drug; challenges phospholipid ... See more keywords

Phospholipid-Based Prodrugs for Colon-Targeted Drug Delivery: Experimental Study and In-Silico Simulations

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recommendations! Published in 2019 at "Pharmaceutics"

DOI: 10.3390/pharmaceutics11040186

Abstract: In ulcerative colitis (UC), the inflammation is localized in the colon, and one of the successful strategies for colon-targeting drug delivery is the prodrug approach. In this work, we present a novel phospholipid (PL)-based prodrug… read more here.

Keywords: based prodrugs; drug delivery; pla2; colon ... See more keywords