Peptide-Based PROTAC: The Predator of Pathological Proteins.
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DOI: 10.1016/j.chembiol.2020.06.002
Abstract: Qu et al. (2020) demonstrate a peptide-induced targeted degradation of the alpha-synuclein protein, a hallmark of Parkinson's disease. Using a modular three-component design, the target-protein-specific, cell-permeable peptide disposed of alpha-synuclein via the ubiquitin-proteasome pathway rather than… read more here.
Keywords: protac predator; based protac; peptide based; pathological proteins ... See more keywords