Developments of CRBN-based PROTACs as potential therapeutic agents.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113749
Abstract: Protease-targeted chimeras (PROTACs) are a new technology that is receiving much attention in the treatment of diseases. The mechanism is to inhibit protein function by hijacking the ubiquitin E3 ligase for protein degradation. Heterogeneous bifunctional… read more here.
Keywords: based protacs; crbn based; developments crbn; protacs potential ... See more keywords
Indomethacin-based PROTACs as pan-coronavirus antiviral agents
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Medicinal Chemistry"
DOI: 10.1016/j.ejmech.2021.113814
Abstract: Indomethacin (INM), a well-known non-steroidal anti-inflammatory drug, has recently gained attention for its antiviral activity demonstrated in drug repurposing studies against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Although the mechanism of action of INM is… read more here.
Keywords: based protacs; pan coronavirus; inm; protacs ... See more keywords
Persistent Degradation of HER2 Protein by Hybrid nanoPROTAC for Programmed Cell Death.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c00013
Abstract: Proteolysis-targeting chimera (PROTAC) has emerged as a promising strategy for degrading proteins of interest. Peptide-based PROTACs offer several advantages over small-molecule-based PROTACs, such as high specificity, low toxicity, and large protein-protein interaction surfaces. However, peptide-based… read more here.
Keywords: peptide based; cell; her2; based protacs ... See more keywords
Recent advances in IAP-based PROTACs (SNIPERs) as potential therapeutic agents
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2074414
Abstract: Abstract Proteolytic targeting chimaeras (PROTACs) have been developed as an effective technology for targeted protein degradation. PROTACs are heterobifunctional molecules that can trigger the polyubiquitination of proteins of interest (POIs) by recruiting the ubiquitin-proteasome system,… read more here.
Keywords: protacs; advances iap; based protacs; therapeutic agents ... See more keywords
Peptide-based PROTACs: Current Challenges and Future Perspectives.
Sign Up to like & getrecommendations! Published in 2023 at "Current medicinal chemistry"
DOI: 10.2174/0929867330666230130121822
Abstract: Proteolysis-targeting chimeras (PROTACs) are an attractive means to target previously undruggable or drug-resistant mutant proteins. While small molecule-based PROTACs are stable and can cross cell membranes, there is limited availability of suitable small molecule warheads… read more here.
Keywords: peptide based; small molecule; protacs current; based protacs ... See more keywords