Selective C–H fluoroalkylation of azines enabled by tailored phosphorus-based reagents
Sign Up to like & getrecommendations! Published in 2021 at "Chem"
DOI: 10.1016/j.chempr.2021.05.011
Abstract: The installation of –CF3 or –CF2H groups into compounds can impact important biologically relevant properties. In a recent paper published in Nature, McNally, Paton, and co-workers introduce novel phosphine-based reagents that allow for the conversion… read more here.
Keywords: fluoroalkylation azines; based reagents; selective fluoroalkylation; azines enabled ... See more keywords
Coupling of 1-Chloro-N,N-diisopropylphosphanamine-Based Reagents with Alcohols and Thiosulfonates: A Precise Construction of O-P(O)-S Bonds.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01947
Abstract: Herein, we present the first mild, one-step direct synthesis of mixed phosphorothioates through selective generation of O-P(O)-S bonds at rt under additive-free condition. Further, reactions of different model natural products with 1,1-dichloro-N,N-diisopropylphosphanamine helped to present… read more here.
Keywords: diisopropylphosphanamine; coupling chloro; synthesis mixed; chloro diisopropylphosphanamine ... See more keywords
2H-Azirine-based Reagents for Chemoselective Bioconjugation at Carboxyl Residues inside Live Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b12116
Abstract: Protein modification by chemical reagents has played an essential role in the treatment of human diseases. However, the reagents currently used are limited to the covalent modification of cysteine and lysine residues. It is thus… read more here.
Keywords: reagents chemoselective; azirine based; based reagents; carboxyl residues ... See more keywords