A CRISPR-Cas9 based shuffle system for endogenous histone H3 and H4 combinatorial mutagenesis
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DOI: 10.1038/s41598-021-82774-4
Abstract: Post-translational modifications of histone proteins greatly impact gene expression and cell fate decisions in eukaryotes. To study these, it is important to develop a convenient, multiplex, and efficient method to precisely introduce mutations to histones.… read more here.
Keywords: cas9 based; based shuffle; crispr cas9; shuffle system ... See more keywords