A Review of pH-Responsive Organic-Inorganic Hybrid Nanoparticles for RNAi-Based Therapeutics.
Sign Up to like & getrecommendations! Published in 2021 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202100183
Abstract: RNA interference (RNAi) shows great potential in the treatment of varying cancer and genetic disorders. The lack of safe and effective delivery methods is an ongoing challenge to realize the full potential of RNAi-based therapeutics.… read more here.
Keywords: organic inorganic; delivery; responsive organic; based therapeutics ... See more keywords
The growth of siRNA-based therapeutics: updated clinical studies.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114432
Abstract: More than two decades after the natural gene-silencing mechanism of RNA interference was elucidated, small interfering RNA (siRNA)-based therapeutics have finally broken into the pharmaceutical market. With three agents already approved and many others in… read more here.
Keywords: clinical studies; sirna based; growth sirna; based therapeutics ... See more keywords
Nature-based therapeutics: A collaborative research agenda promoting equitable access and environmental stewardship
Sign Up to like & getrecommendations! Published in 2021 at "Collegian"
DOI: 10.1016/j.colegn.2021.03.001
Abstract: ABSTRACT Background Given the duration and intensity of the COVID-19 pandemic, with strict emphasis on social distancing, many individuals and families are experiencing social isolation. The need to explore effective strategies for health promotion and… read more here.
Keywords: research; nature based; based therapeutics; nature ... See more keywords
Discovery of targeted expression data for novel antibody-based and chimeric antigen receptor-based therapeutics in soft tissue sarcomas using RNA-sequencing: clinical implications.
Sign Up to like & getrecommendations! Published in 2021 at "Current problems in cancer"
DOI: 10.1016/j.currproblcancer.2021.100794
Abstract: Recent failure of phase 3 trials and paucity of druggable oncogenic drivers hamper developmental therapeutics in sarcomas. Antibody-based therapeutics, like antibody-drug conjugates (ADCs) and chimeric antigen receptor (CAR)-based therapeutics, have emerged as promising strategies for… read more here.
Keywords: antibody based; based therapeutics; expression; antigen receptor ... See more keywords
Peptide-based therapeutics: quality specifications, regulatory considerations, and prospects.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2018.10.002
Abstract: Exquisite selectivity, remarkable efficacy, and minimal toxicity are key attributes inherently assigned to peptides, resulting in increased research interest from the pharmaceutical industry in peptide-based therapeutics (PbTs). Pharmacopoeias develop authoritative standards for PbT by providing… read more here.
Keywords: specifications regulatory; based therapeutics; peptide based; therapeutics quality ... See more keywords
Synthetic access to thiolane-based therapeutics and biological activity studies.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113659
Abstract: Secondary metabolites isolated from bioactive extracts of natural sources iteratively pioneer the research in drug discovery. Modern medicine is often inspired by bioactive natural products or the bio-functional motifs embedded in them. One of such… read more here.
Keywords: thiolane based; biological activity; activity studies; based therapeutics ... See more keywords
Cell based therapeutics in type 1 diabetes mellitus.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.02.063
Abstract: This review focuses on Type 1 diabetes mellitus (T1DM) and the role of bioengineering, nanotechnology and cell therapy in its treatment. T1DM is discussed in terms of its prevalence as well as the role of… read more here.
Keywords: therapeutics type; based therapeutics; cell based; type diabetes ... See more keywords
Oral delivery of protein-based therapeutics: Gastroprotective strategies, physiological barriers and in vitro permeability prediction.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119488
Abstract: The number of biological molecules emerging as therapeutics is growing exponentially due to their higher specificity and tolerability profiles compared to small molecules. Despite this, their traditionally parenteral delivery often results in poor patient compliance… read more here.
Keywords: oral delivery; protein based; delivery; based therapeutics ... See more keywords
Applying recent advances in the science of CFTR-based therapeutics to improve outcomes in patients with cystic fibrosis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cystic Fibrosis"
DOI: 10.1016/j.jcf.2017.03.002
Abstract: Abstract The content for this activity is based on the satellite symposium, “Applying Recent Advances in the Science of CFTR-based Therapeutics to Improve Outcomes in Patients With Cystic Fibrosis”, that was presented at the 30th… read more here.
Keywords: cystic fibrosis; fibrosis; based therapeutics; cftr based ... See more keywords
Inactivated tetanus as an immunological smokescreen: A major step towards harnessing tetanus-based therapeutics.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.09.008
Abstract: BACKGROUND AND PURPOSE Tetanus neurotoxin has many potential therapeutic applications, due to its ability to increase localised muscle tone when injected directly into a muscle. It is a closely related molecule to botulinum neurotoxin (most… read more here.
Keywords: major step; based therapeutics; tetanus toxin; toxin ... See more keywords
Albumin-Based Therapeutics Capable of Glutathione Consumption and Hydrogen Peroxide Generation for Synergetic Chemodynamic and Chemotherapy of Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.1c08536
Abstract: A nanoscale therapeutic system with good biocompatibility was facilely fabricated by the coassembly of human serum albumin and glucose oxidase (GOD), where the former was pretreated with metal ions through a chelating agent or the… read more here.
Keywords: hydrogen peroxide; consumption; hydrogen; based therapeutics ... See more keywords