Synthesis and evaluation of novel xanthene‐based thiazoles as potential antidiabetic agents
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DOI: 10.1002/ardp.202200356
Abstract: A series of xanthene‐based thiazoles was synthesized and characterized by different scpectroscopic methods, i.e. Proton nuclear magnetic resonance (1H NMR), carbon nuclear magnetic resonance (13C NMR), infrared spectroscopy, carbon hydrogen nitrogen analysis, and X‐ray crystallography.… read more here.
Keywords: evaluation novel; xanthene based; novel xanthene; based thiazoles ... See more keywords
Discovery of New 3,3-Diethylazetidine-2,4-dione Based Thiazoles as Nanomolar Human Neutrophil Elastase Inhibitors with Broad-Spectrum Antiproliferative Activity
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DOI: 10.3390/ijms23147566
Abstract: A series of 3,3-diethylazetidine-2,4-dione based thiazoles 3a–3j were designed and synthesized as new human neutrophil elastase (HNE) inhibitors in nanomolar range. The representative compounds 3c, 3e, and 3h exhibit high HNE inhibitory activity with IC50… read more here.
Keywords: diethylazetidine dione; neutrophil elastase; human neutrophil; based thiazoles ... See more keywords