Label-free monitoring of DNA polymerase activity based on a thrombin-binding aptamer G-quadruplex.
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DOI: 10.1016/j.mcp.2016.10.010
Abstract: We have developed a label-free assay for the detection of DNA polymerase activity based on a thrombin-binding aptamer (TBA) G-quadruplex. In the presence of DNA polymerase, the 3'-OH termini of the hairpin substrate are immediately… read more here.
Keywords: based thrombin; activity based; dna polymerase; polymerase ... See more keywords
Pyrazole-Based Thrombin Inhibitors with a Serine-Trapping Mechanism of Action: Synthesis and Biological Activity
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DOI: 10.3390/ph15111340
Abstract: New antithrombotic drugs are needed to combat thrombosis, a dangerous pathology that causes myocardial infarction and ischemic stroke. In this respect, thrombin (FIIa) represents an important drug target. We herein report the synthesis and biological… read more here.
Keywords: synthesis biological; thrombin inhibitors; biological activity; inhibitors serine ... See more keywords