Post-transplantation cyclophosphamide for chimerism-based tolerance
Sign Up to like & getrecommendations! Published in 2019 at "Bone Marrow Transplantation"
DOI: 10.1038/s41409-019-0615-0
Abstract: High-dose cyclophosphamide given post-transplant (PTCy) successfully enables tolerance induction in HLA-mismatched related blood or marrow transplantation (haploBMT) manifested by low rates of graft failure, severe acute graft-versus-host disease (GVHD), and chronic GVHD. When proceeded by… read more here.
Keywords: based tolerance; transplantation; chimerism based; ptcy ... See more keywords
Accelerating sampling-based tolerance–cost optimization by adaptive surrogate models
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DOI: 10.1080/0305215x.2024.2306142
Abstract: ABSTRACT High numbers of function evaluations are inevitable to guarantee the reliability and optimality of sampling-based tolerance–cost optimization. Despite using different countermeasures to increase its efficiency, unreasonably long computation times and unreliable results currently hinder… read more here.
Keywords: based tolerance; optimization; tolerance cost; sampling based ... See more keywords
Chimerism-based Tolerance Induction in Clinical Transplantation: Its Foundations and Mechanisms.
Sign Up to like & getrecommendations! Published in 2023 at "Transplantation"
DOI: 10.1097/tp.0000000000004589
Abstract: Hematopoietic chimerism remains the most promising strategy to bring transplantation tolerance into clinical routine. The concept of chimerism-based tolerance aims to extend the recipient's mechanisms of self-tolerance (ie, clonal deletion, anergy, and regulation) to include… read more here.
Keywords: chimerism; based tolerance; transplantation; tolerance ... See more keywords