Temperature effect on perfluorooctane sulfonate toxicokinetics in rainbow trout (Oncorhynchus mykiss): Exploration via a physiologically based toxicokinetic model.
Sign Up to like & getrecommendations! Published in 2020 at "Aquatic toxicology"
DOI: 10.1016/j.aquatox.2020.105545
Abstract: Salmonids are poikilotherms, which means that their internal temperature varies with that of water. Water temperature thus controls many of their lifecycle processes and physiological functions, which could influence the mechanisms of absorption, distribution, metabolism… read more here.
Keywords: temperature; physiologically based; rainbow trout; trout oncorhynchus ... See more keywords
Physiologically Based Toxicokinetic Modeling of Bisphenols in Zebrafish (Danio rerio) Accounting for Variations in Metabolic Rates, Brain Distribution, and Liver Accumulation
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Science & Technology"
DOI: 10.1021/acs.est.2c01292
Abstract: Bisphenol A (BPA) is an industrial chemical, which has raised human health and environmental concerns due to its endocrine-disrupting properties. BPA analogues are less well-studied despite their wide use in consumer products. These analogues have… read more here.
Keywords: brain; physiologically based; danio rerio; based toxicokinetic ... See more keywords
Mechanistic Middle-Out Physiologically Based Toxicokinetic Modeling of Transporter-Dependent Disposition of Perfluorooctanoic Acid in Humans
Sign Up to like & getrecommendations! Published in 2023 at "Environmental Science & Technology"
DOI: 10.1021/acs.est.2c05642
Abstract: Perfluorooctanoic acid (PFOA) is an environmental toxicant exhibiting a years-long biological half-life (t1/2) in humans and is linked with adverse health effects. However, limited understanding of its toxicokinetics (TK) has obstructed the necessary risk assessment.… read more here.
Keywords: middle physiologically; transporter; based toxicokinetic; physiologically based ... See more keywords