Design, synthesis, and in vitro and in vivo anti-angiogenesis study of a novel vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor based on 1,2,3-triazole scaffold.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.113083
Abstract: In the past five years, our team had been committed to click chemistry research, exploring the biological activity of 1,2,3-triazole by synthesizing different target inhibitors. In this study, a series of novel indole-2-one derivatives based… read more here.
Keywords: anti angiogenesis; chemistry; compound 13d; vegfr ... See more keywords
Highly efficient flame-retardant epoxy resin with a novel DOPO-based triazole compound: Thermal stability, flame retardancy and mechanism
Sign Up to like & getrecommendations! Published in 2017 at "Polymer Degradation and Stability"
DOI: 10.1016/j.polymdegradstab.2017.01.014
Abstract: Abstract A novel 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO)-based triazole compound (DTA) was prepared by reacting DOPO with imine obtained from the condensation of terephthalaldehyde with 3-amino-1H-1,2,4-triazole. Its chemical structure was characterized by FTIR, 1H NMR, 13C NMR, 31P… read more here.
Keywords: dta; flame retardant; mechanism; flame ... See more keywords
2-aminofluorene based triazole cocktailed with organosilane as UV-Visible and fluorescence sensor for highly selective detection of Fe(III) ion and its anti-leishmanial activity
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DOI: 10.1039/d3nj00105a
Abstract: In current work, we have developed a new 2-aminofluorene-based triazole attached organosilanes with the click chemistry approach and newly synthesized compounds are comprehensively studied using NMR (1H and 13C), TGA,... read more here.
Keywords: based triazole; aminofluorene based; chemistry; triazole cocktailed ... See more keywords
QSAR Study of New Compounds Based on 1,2,4-Triazole as Potential Anticancer Agents
Sign Up to like & getrecommendations! Published in 2020 at "Physical Chemistry Research"
DOI: 10.22036/pcr.2019.204753.1685
Abstract: Pancreatic cancer is an aggressive cancer, usually with poor prognosis, as it is mostly discovered at an advanced stage of development where treatment is challenging. Using principal components analysis (PCA) of variable selection, multiple linear… read more here.
Keywords: based triazole; qsar study; qsar models; compounds based ... See more keywords