Discovery of Novel Acridane-Based Tubulin Polymerization Inhibitors with Anticancer and Potential Immunomodulatory Effects.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01566
Abstract: A series of novel acridane-based tubulin polymerization inhibitors were designed, synthesized, and bioevaluated as anticancer agents. The most potent compound NT-6 exhibited high tubulin polymerization inhibitory activity (IC50 = 1.5 μM) and remarkable antiproliferative potency… read more here.
Keywords: polymerization inhibitors; based tubulin; tubulin polymerization; acridane based ... See more keywords
Indole-Based Tubulin Inhibitors: Binding Modes and SARs Investigations
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DOI: 10.3390/molecules27051587
Abstract: Tubulin inhibitors can interfere with normal cell mitosis and inhibit cell proliferation through interfering with the normal structure and function of microtubules, forming spindle filaments. Indole, as a privileged pharmacological skeleton, has been widely used… read more here.
Keywords: tubulin inhibitors; based tubulin; modes sars; tubulin ... See more keywords