Discovery of triazole-based uracil derivatives bearing amide moieties as novel dipeptidyl peptidase-IV inhibitors.
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DOI: 10.1016/j.bioorg.2017.10.010
Abstract: Dipeptidyl peptidase-IV (DPP-4) is a validated target for T2DM treatment. We previously reported a novel series of triazole-based uracil derivatives bearing aliphatic carboxylic acids with potent DPP-4 inhibitory activities in vitro, but these compounds showed… read more here.
Keywords: dpp; based uracil; compound; triazole based ... See more keywords