The adjuvant effect of melanin is superior to incomplete Freund’s adjuvant in subunit/peptide vaccines in mice
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-020-02631-7
Abstract: Peptide vaccines represent an attractive alternative to conventional anti-tumor therapies, but have not yet achieved significant clinical efficacy with commonly used formulations. Combination of short antigenic peptides, synthetic melanin and TLR9 agonist (Toll-like receptor 9,… read more here.
Keywords: incomplete freund; based vaccine; melanin; peptide vaccines ... See more keywords
A Vector-Based Vaccine Dose After 3 Doses of mRNA-Based COVID-19 Vaccination Does Not Substantially Improve Humoral SARS-CoV-2 Immunity in Renal Transplant Recipients
Sign Up to like & getrecommendations! Published in 2022 at "Kidney International Reports"
DOI: 10.1016/j.ekir.2022.01.1068
Abstract: To the Editor: COVID-19–related mortality in kidney transplant recipients (KTX) is significantly higher when compared with nontransplant patients. Vaccination against SARS-CoV-2 is the most efficient measure to protect this vulnerable population. Nevertheless, after the application… read more here.
Keywords: transplant recipients; based vaccine; vaccination; mrna based ... See more keywords
In silico design of an epitope-based vaccine against choline binding protein A of Streptococcus pneumoniae
Sign Up to like & getrecommendations! Published in 2021 at "Informatics in Medicine Unlocked"
DOI: 10.1016/j.imu.2021.100546
Abstract: Abstract Streptococcus pneumoniae (Pneumococcus) accounts for a major global health burden that causes bacterial pneumonia, sepsis, otitis media, and meningitis. It is responsible for great morbidity and mortality globally. Available pneumonia vaccines are either carbohydrate-based… read more here.
Keywords: epitope based; streptococcus pneumoniae; based vaccine; binding protein ... See more keywords
Coating With Chitooligosaccharides Enhances the Cytokine Induction of Listeria ivanovii-Based Vaccine Strain.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2019.04.011
Abstract: Listeria ivanovi (LI) is an available live bacterial vaccine vector. This work attempted to coat LI-based vaccine candidates (LI-Rv0129c) with chitooligosaccharides (COSs) as an adjuvant to enhance the cellular immune responses induced. COS-bacteria composite was… read more here.
Keywords: based vaccine; listeria; chitooligosaccharides enhances; strain ... See more keywords
Synthesis and Evaluation of a QS-17/18-Based Vaccine Adjuvant.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01997
Abstract: We have synthesized a QS-17/18 analogue (7) and evaluated its adjuvant activity in the formulation with rHagB antigen. Compound 7 and QS-21 analogues 5 and 6 are presumably the major components of GPI-0100, a widely… read more here.
Keywords: based vaccine; evaluation based; vaccine adjuvant; gpi 0100 ... See more keywords
Diabetes: Towards a coxsackievirus B-based vaccine to combat T1DM
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Endocrinology"
DOI: 10.1038/nrendo.2017.184
Abstract: The role of group B coxsackieviruses (CVB) in the pathogenesis of type 1 diabetes mellitus (T1DM) remains controversial. A recent report by Stone et al. showed that a CVB1-based vaccine can protect against both CVB1… read more here.
Keywords: diabetes towards; based vaccine; towards coxsackievirus; coxsackievirus based ... See more keywords
A multivalent T-antigen-based vaccine for Group A Streptococcus
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-83673-4
Abstract: Pili of Group A Streptococcus (GAS) are surface-exposed structures involved in adhesion and colonisation of the host during infection. The major protein component of the GAS pilus is the T-antigen, which multimerises to form the… read more here.
Keywords: based vaccine; antigen based; group streptococcus; antigen ... See more keywords
Synthesis of Multicomponent Peptide-Based Vaccine Candidates against Group A Streptococcus
Sign Up to like & getrecommendations! Published in 2017 at "Australian Journal of Chemistry"
DOI: 10.1071/ch16501
Abstract: Group A streptococcus (GAS; Streptococcus pyogenes), known as the ‘flesh-eating bacterium’, is a human bacterial pathogen that normally causes benign infections (e.g. sore throat and pyoderma), but is also responsible for severe invasive infections (e.g.… read more here.
Keywords: based vaccine; group streptococcus; gas; peptide based ... See more keywords
Exploring dengue proteome to design an effective epitope-based vaccine against dengue virus
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2018.1491890
Abstract: Abstract Dengue, a mosquito-borne disease, is caused by four known dengue serotypes. This infection causes a range of symptoms from a mild fever to a sever homorganic fever and death. It is a serious public… read more here.
Keywords: dengue virus; based vaccine; vaccine dengue; design effective ... See more keywords
Dendritic cell-based vaccine: the state-of-the-art vaccine platform for COVID-19 management
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Vaccines"
DOI: 10.1080/14760584.2022.2110076
Abstract: ABSTRACT Introduction A correlation between new coronaviruses and host immunity, as well as the role of defective immune function in host response, would be extremely helpful in understanding coronavirus disease (COVID-19) pathogenicity, and a coherent… read more here.
Keywords: cell based; dendritic cell; covid; based vaccine ... See more keywords
EXTH-43. GENERATION OF A B-CELL-BASED VACCINE FOR THE TREATMENT OF GLIOBLASTOMA
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.397
Abstract: Immunotherapy has revolutionized the treatment of many tumors. However, most glioblastoma (GBM) patients have not, so far, benefited from such successes. With the goal of exploring ways to boost anti-GBM immunity, we developed a B-cell-based… read more here.
Keywords: based vaccine; treatment; cell based; cell ... See more keywords