Atg8–PE protein-based in vitro biochemical approaches to autophagy studies
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2025572
Abstract: ABSTRACT Macroautophagy/autophagy is an evolutionarily conserved intracellular degradation pathway that maintains cellular homeostasis. Over the past two decades, a series of scientific breakthroughs have helped explain autophagy-related molecular mechanisms and physiological functions. This tremendous progress… read more here.
Keywords: autophagy studies; atg8 protein; based vitro; protein based ... See more keywords
High Throughput Fluorescence-Based In Vitro Experimental Platform for the Identification of Effective Therapies to Overcome Tumour Microenvironment-Mediated Drug Resistance in AML
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DOI: 10.3390/cancers15071988
Abstract: Simple Summary The interactions between Acute Myeloid Leukaemia (AML) cells and the surrounding bone marrow (BM) tissue contribute to blocking the efficacy of current drug treatments and to the relapse of patients. Relapsing AML tumours… read more here.
Keywords: microenvironment; based vitro; aml cells; resistance ... See more keywords
In Vitro/In Vivo Translation of Synergistic Combination of MDM2 and MEK Inhibitors in Melanoma Using PBPK/PD Modelling: Part II
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DOI: 10.3390/ijms231911939
Abstract: The development of in vitro/in vivo translational methods for synergistically acting drug combinations is needed to identify the most effective therapeutic strategies. We performed PBPK/PD modelling for siremadlin, trametinib, and their combination at various dose… read more here.
Keywords: vitro vivo; pbpk modelling; based vitro; combination ... See more keywords