Unexpected Solubility Enhancement of Drug Bases in the Presence of a Dimethylaminoethyl Methacrylate Copolymer.
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DOI: 10.1021/acs.molpharmaceut.7b00804
Abstract: The methacrylate copolymer Eudragit EPO (EPO) has previously shown to greatly enhance solubilization of acidic drugs via ionic interactions and by multiple hydrophobic contacts with polymeric side chains. The latter type of interaction could also… read more here.
Keywords: presence; methacrylate copolymer; drug; solubility enhancement ... See more keywords