Basic domain of telomere guardian TRF2 reduces D-loop unwinding whereas Rap1 restores it
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx812
Abstract: Abstract Telomeric repeat binding factor 2 (TRF2) folds human telomeres into loops to prevent unwanted DNA repair and chromosome end-joining. The N-terminal basic domain of TRF2 (B-domain) protects the telomeric displacement loop (D-loop) from cleavage… read more here.
Keywords: basic domain; dna; domain trf2; loop ... See more keywords
Functional Characterization of an In-Frame Deletion in the Basic Domain of the Retinal Transcription Factor ATOH7
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DOI: 10.3390/ijms23031053
Abstract: Basic helix–loop–helix (bHLH) transcription factors are evolutionarily conserved and structurally similar proteins important in development. The temporospatial expression of atonal bHLH transcription factor 7 (ATOH7) directs the differentiation of retinal ganglion cells and mutations in… read more here.
Keywords: transcription factor; transcription; basic domain; frame deletion ... See more keywords