Developing a Formulation Strategy Coupled with PBPK Modeling and Simulation for the Weakly Basic Drug Albendazole
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DOI: 10.3390/pharmaceutics15041040
Abstract: Albendazole (ABZ) is a weakly basic drug that undergoes extensive presystemic metabolism after oral administration and converts to its active form albendazole sulfoxide (ABZ_SO). The absorption of albendazole is limited by poor aqueous solubility, and… read more here.
Keywords: formulation; pbpk modeling; basic drug; abz ... See more keywords
Biomimetic Nanoparticles for Basic Drug Delivery
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DOI: 10.3390/pharmaceutics16101306
Abstract: Biomimetic nanoparticles (BMNPs) are innovative nanovehicles that replicate the properties of naturally occurring extracellular vesicles, facilitating highly efficient drug delivery across biological barriers to target organs and tissues while ensuring maximal biocompatibility and minimal-to-no toxicity.… read more here.
Keywords: nanoparticles basic; drug delivery; delivery; basic drug ... See more keywords