Enantioseparation of basic drugs by reverse phase high-performance liquid chromatography system using carboxymethyl-β-cyclodextrin as chiral mobile phase additive.
Sign Up to like & getrecommendations! Published in 2022 at "Chirality"
DOI: 10.1002/chir.23470
Abstract: A rapid and efficient method was developed for enantioseparation of basic drugs, using carboxymethyl-β-cyclodextrin (CM-β-CD) as chiral mobile phase additive, rather than involving costly chiral column in high-performance liquid chromatography (HPLC) system. Four of the… read more here.
Keywords: enantioseparation basic; phase; mobile phase; using carboxymethyl ... See more keywords
In‐line coupling of supported liquid membrane extraction across nanofibrous membrane to capillary electrophoresis for analysis of basic drugs from undiluted body fluids
Sign Up to like & getrecommendations! Published in 2018 at "ELECTROPHORESIS"
DOI: 10.1002/elps.201800487
Abstract: Planar polyamide 6 nanofibrous membrane was for the first time used in direct coupling of supported liquid membrane (SLM) extraction to CE analysis. Disposable microextraction device with the nanofibrous membrane was preassembled and stored for… read more here.
Keywords: extraction; supported liquid; basic drugs; coupling supported ... See more keywords
Semi-automated set-up for exhaustive micro-electromembrane extractions of basic drugs from biological fluids.
Sign Up to like & getrecommendations! Published in 2018 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2017.11.081
Abstract: Manual handling of microliter volumes of samples and reagents is usually prone to errors and may have direct consequence on the overall performance of microextraction process. Direct connection of a syringe pump and a disposable… read more here.
Keywords: micro electromembrane; basic drugs; solution; semi automated ... See more keywords
Investigation of alternative supported liquid membranes in electromembrane extraction of basic drugs from human plasma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Membrane Science"
DOI: 10.1016/j.memsci.2017.11.001
Abstract: Abstract For the first time, supported liquid membranes (SLMs) of phthalate- and nitrile-based organic solvents were investigated for electromembrane extraction (EME) of eleven polar and non-polar basic drugs from human plasma (pH 7.4). Several phthalates… read more here.
Keywords: supported liquid; basic drugs; human plasma; electromembrane extraction ... See more keywords
Exploring Multi-Compartment Plug-Flow Based Model Approach in Biopharmaceutics: Impact of Stomach Setting and the Estimation of the Fraction Absorbed of Orally Administered Basic Drugs.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2019.11.021
Abstract: There has been an increasing interest in accurate prediction of human pharmacokinetics (PK) of drug candidates in order to reduce cost and increase productivity during research and development. Modeling efforts have primarily focused on predicting… read more here.
Keywords: compartment plug; multi compartment; basic drugs; compartment ... See more keywords
Use of Gastrointestinal Simulator, Mass Transport Analysis, and Absorption Simulation to Investigate the Impact of pH Modifiers in Mitigating Weakly Basic Drugs' Performance Issues Related to Gastric pH: Palbociclib Case Study.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00545
Abstract: It is well known that reduced gastric acidity, for example with concomitant administration of acid reducing agents, can result in variable pharmacokinetics and decreased absorption of weakly basic drugs. It is important to identify the… read more here.
Keywords: dissolution; palbociclib; modifiers mitigating; absorption ... See more keywords
Design and Optimization of a Nanoparticulate Pore Former as a Multifunctional Coating Excipient for pH Transition-Independent Controlled Release of Weakly Basic Drugs for Oral Drug Delivery
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15020547
Abstract: Bioavailability of weakly basic drugs may be disrupted by dramatic pH changes or unexpected pH alterations in the gastrointestinal tract. Conventional organic acids or enteric coating polymers cannot address this problem adequately because they leach… read more here.
Keywords: transition; controlled release; release; drug ... See more keywords