Structural basis for the activity and regulation of human α-ketoglutarate dehydrogenase revealed by Cryo-EM.
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DOI: 10.1016/j.bbrc.2022.02.093
Abstract: The human mitochondrial alpha-ketoglutarate (α-KG) dehydrogenase complex (hKGDHc) is a well-studied macromolecular enzyme that converts α-KG to succinyl-CoA and NADH. Abnormalities of the complex lead to several diseases, including neurodegenerative disorders. Despite its importance in… read more here.
Keywords: regulation human; activity regulation; structural basis; dehydrogenase ... See more keywords