Structural basis for allosteric regulation of Human Topoisomerase IIα
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23136-6
Abstract: The human type IIA topoisomerases (Top2) are essential enzymes that regulate DNA topology and chromosome organization. The Topo IIα isoform is a prime target for antineoplastic compounds used in cancer therapy that form ternary cleavage… read more here.
Keywords: human topoisomerase; structural basis; allosteric regulation; basis allosteric ... See more keywords
Structural basis for allosteric control of the SERCA-Phospholamban membrane complex by Ca2+ and phosphorylation
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.66226
Abstract: Phospholamban (PLN) is a mini-membrane protein that directly controls the cardiac Ca2+-transport response to β-adrenergic stimulation, thus modulating cardiac output during the fight-or-flight response. In the sarcoplasmic reticulum membrane, PLN binds to the sarco(endo)plasmic reticulum… read more here.
Keywords: phosphorylation; membrane; basis allosteric; ca2 ... See more keywords