Molecular Basis of Broad Spectrum N-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2
Sign Up to like & getrecommendations! Published in 2019 at "ACS Central Science"
DOI: 10.1021/acscentsci.8b00917
Abstract: Immunoglobulin G (IgG) glycosylation critically modulates antibody effector functions. Streptococcus pyogenes secretes a unique endo-β-N-acetylglucosaminidase, EndoS2, which deglycosylates the conserved N-linked glycan at Asn297 on IgG Fc to eliminate its effector functions and evade the… read more here.
Keywords: glycan specificity; molecular basis; spectrum glycan; broad spectrum ... See more keywords
Structural basis for the broad substrate specificity of the human tyrosylprotein sulfotransferase-1
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-07141-8
Abstract: Tyrosylprotein sulfotransferases (TPSTs) are enzymes that catalyze post-translational tyrosine sulfation of proteins. In humans, there are only two TPST isoforms, designated TPST1 and TPST2. In a previous study, we reported the crystal structure of TPST2,… read more here.
Keywords: structural basis; broad substrate; tyrosylprotein; sulfation ... See more keywords