Molecular basis of the evolution of alternative tyrosine biosynthetic routes in plants.
Sign Up to like & getrecommendations! Published in 2017 at "Nature chemical biology"
DOI: 10.1038/nchembio.2414
Abstract: L-Tyrosine (Tyr) is essential for protein synthesis and is a precursor of numerous specialized metabolites crucial for plant and human health. Tyr can be synthesized via two alternative routes by different key regulatory TyrA family… read more here.
Keywords: evolution alternative; molecular basis; tyrosine; tyr ... See more keywords
Genomic and structural basis for evolution of tropane alkaloid biosynthesis.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2302448120
Abstract: The tropane alkaloids (TAs) cocaine and hyoscyamine have been used medicinally for thousands of years. To understand the evolutionary origins and trajectories of serial biosynthetic enzymes of TAs and especially the characteristic tropane skeletons, we… read more here.
Keywords: biosynthesis; genomic structural; structural basis; analysis ... See more keywords
Metabolic basis for the evolution of a common pathogenic Pseudomonas aeruginosa variant
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.76555
Abstract: Microbes frequently evolve in reproducible ways. Here, we show that differences in specific metabolic regulation explain the frequent presence of lasR loss-of-function mutations in the bacterial pathogen Pseudomonas aeruginosa. While LasR contributes to virulence, lasR… read more here.
Keywords: lasr; pseudomonas aeruginosa; metabolic basis; evolution ... See more keywords