Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis.
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DOI: 10.1021/jacs.8b06623
Abstract: Oxidative rearrangements play key roles in introducing structural complexity and biological activities of natural products biosynthesized by type II polyketide synthases (PKSs). Chartreusin (1) is a potent antitumor polyketide that contains a unique rearranged pentacyclic… read more here.
Keywords: biosynthesis; molecular basis; oxidative rearrangement; basis final ... See more keywords