Molecular basis of the human ribosomopathy Shwachman-Diamond syndrome
Sign Up to like & getrecommendations! Published in 2018 at "Advances in Biological Regulation"
DOI: 10.1016/j.jbior.2017.09.002
Abstract: Mutations that target the ubiquitous process of ribosome assembly paradoxically cause diverse tissue-specific disorders (ribosomopathies) that are often associated with an increased risk of cancer. Ribosomes are the essential macromolecular machines that read the genetic… read more here.
Keywords: diamond syndrome; molecular basis; shwachman diamond; basis human ... See more keywords
Structural basis of human PCNA sliding on DNA
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DOI: 10.1038/ncomms13935
Abstract: Sliding clamps encircle DNA and tether polymerases and other factors to the genomic template. However, the molecular mechanism of clamp sliding on DNA is unknown. Using crystallography, NMR and molecular dynamics simulations, here we show… read more here.
Keywords: pcna; structural basis; dna; clamp ... See more keywords
Genetic and structural basis of the human anti-α-galactosyl antibody response
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123212119
Abstract: Significance The immune response to Galα1–3Galβ1–4GlcNAc (α-gal) has been linked to human allergy and inflammation, and to resistance to xenotransplantation and infection. Here we investigate structural and genetic features that shape the antibody response to… read more here.
Keywords: antibody response; basis human; genetic structural; structural basis ... See more keywords
Intracerebral Electrophysiological Recordings to Understand the Neural Basis of Human Face Recognition
Sign Up to like & getrecommendations! Published in 2023 at "Brain Sciences"
DOI: 10.3390/brainsci13020354
Abstract: Understanding how the human brain recognizes faces is a primary scientific goal in cognitive neuroscience. Given the limitations of the monkey model of human face recognition, a key approach in this endeavor is the recording… read more here.
Keywords: recognition; human face; neural basis; basis human ... See more keywords