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   Articles with "basis human" as a keyword



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Molecular basis of the human ribosomopathy Shwachman-Diamond syndrome

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recommendations! Published in 2018 at "Advances in Biological Regulation"

DOI: 10.1016/j.jbior.2017.09.002

Abstract: Mutations that target the ubiquitous process of ribosome assembly paradoxically cause diverse tissue-specific disorders (ribosomopathies) that are often associated with an increased risk of cancer. Ribosomes are the essential macromolecular machines that read the genetic… read more here.

Keywords: diamond syndrome; molecular basis; shwachman diamond; basis human ... See more keywords
Photo by nci from unsplash

Structural basis of human PCNA sliding on DNA

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recommendations! Published in 2017 at "Nature Communications"

DOI: 10.1038/ncomms13935

Abstract: Sliding clamps encircle DNA and tether polymerases and other factors to the genomic template. However, the molecular mechanism of clamp sliding on DNA is unknown. Using crystallography, NMR and molecular dynamics simulations, here we show… read more here.

Keywords: pcna; structural basis; dna; clamp ... See more keywords

Genetic and structural basis of the human anti-α-galactosyl antibody response

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2123212119

Abstract: Significance The immune response to Galα1–3Galβ1–4GlcNAc (α-gal) has been linked to human allergy and inflammation, and to resistance to xenotransplantation and infection. Here we investigate structural and genetic features that shape the antibody response to… read more here.

Keywords: antibody response; basis human; genetic structural; structural basis ... See more keywords

Molecular basis for human aquaporin inhibition

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recommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2319682121

Abstract: Significance Aquaporins (AQPs) are membrane proteins facilitating flux of water and/or small neutral solutes like glycerol across membranes. Drugs targeting AQPs have broad potential clinical applications, including cancer, obesity, and skin diseases among others. Here,… read more here.

Keywords: aquaporin inhibition; human aquaporin; inhibition; basis human ... See more keywords

Intracerebral Electrophysiological Recordings to Understand the Neural Basis of Human Face Recognition

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recommendations! Published in 2023 at "Brain Sciences"

DOI: 10.3390/brainsci13020354

Abstract: Understanding how the human brain recognizes faces is a primary scientific goal in cognitive neuroscience. Given the limitations of the monkey model of human face recognition, a key approach in this endeavor is the recording… read more here.

Keywords: recognition; human face; neural basis; basis human ... See more keywords

An Editorial on the Special Issue “Genetic Basis of Human Diseases”

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recommendations! Published in 2024 at "Life"

DOI: 10.3390/life14060691

Abstract: The role of heredity in the emergence of the overwhelming majority of human diseases is currently considered proven and has significant importance [...]. read more here.

Keywords: special issue; issue genetic; editorial special; human diseases ... See more keywords