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Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c00587
Abstract: Selective inhibitors of protein kinase CK2 with significant cytotoxicity on tumor cells based on a 2-aminothiazole scaffold were described recently. Here, these studies are supplemented with representative CK2α/CK2α' complex struc-tures. They reveal that the 2-aminothiazole-based…
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Keywords:
kinase ck2;
structural mechanistic;
mechanistic basis;
protein kinase ... See more keywords
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Published in 2022 at "Molecules"
DOI: 10.3390/molecules27154919
Abstract: Naltrexone is a potent opioid antagonist with good blood–brain barrier permeability, targeting different endogenous opioid receptors, particularly the mu-opioid receptor (MOR). Therefore, it represents a promising candidate for drug development against drug addiction. However, the…
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Keywords:
structural energetic;
hmor;
basis inhibitory;
molecular basis ... See more keywords