Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine
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DOI: 10.1093/nar/gkz381
Abstract: Abstract The psychiatric risk-associated transcription factor 4 (TCF4) is linked to schizophrenia. Rare TCF4 coding variants are found in individuals with Pitt-Hopkins syndrome—an intellectual disability and autism spectrum disorder. TCF4 contains a C-terminal basic-helix-loop-helix (bHLH)… read more here.
Keywords: structural basis; dna; tcf4; groove ... See more keywords