Molecular basis of specificity and deamidation of eIF4A by Burkholderia Lethal Factor 1.
Sign Up to like & getrecommendations! Published in 2022 at "Communications biology"
DOI: 10.1038/s42003-022-03186-2
Abstract: Burkholderia pseudomallei lethal factor 1 (BLF1) exhibits site-specific glutamine deamidase activity against the eukaryotic RNA helicase, eIF4A, thereby blocking mammalian protein synthesis. The structure of a complex between BLF1 C94S and human eIF4A shows that… read more here.
Keywords: lethal factor; basis specificity; molecular basis; deamidation eif4a ... See more keywords
Basis of specificity for a conserved and promiscuous chromatin remodeling protein
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.64061
Abstract: Eukaryotic genomes are organized dynamically through the repositioning of nucleosomes. Isw2 is an enzyme that has been previously defined as a genome-wide, nonspecific nucleosome spacing factor. Here, we show that Isw2 instead acts as an… read more here.
Keywords: conserved promiscuous; chromatin; chromatin remodeling; basis specificity ... See more keywords