Structural basis of substrate selectivity of viperin.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00741
Abstract: Viperin is a radical S-adenosylmethionine (SAM) enzyme that inhibits viral replication by converting cytidine triphosphate (CTP) into 3-deoxy-3,4-didehydro-CTP and by additional undefined mechanisms operating through its N- and C-terminal domains. Here, we describe crystal structures… read more here.
Keywords: basis substrate; structural basis; ctp utp; substrate selectivity ... See more keywords
Structural basis for substrate binding and selection by human mitochondrial RNA polymerase
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-50817-9
Abstract: The mechanism by which RNAP selects cognate substrates and discriminates between deoxy and ribonucleotides is of fundamental importance to the fidelity of transcription. Here, we present cryo-EM structures of human mitochondrial transcription elongation complexes that… read more here.
Keywords: site; structural basis; human mitochondrial; basis substrate ... See more keywords