An efficient basket trial design.
Sign Up to like & getrecommendations! Published in 2017 at "Statistics in medicine"
DOI: 10.1002/sim.7227
Abstract: The landscape for early phase cancer clinical trials is changing dramatically because of the advent of targeted therapy. Increasingly, new drugs are designed to work against a target such as the presence of a specific… read more here.
Keywords: drug works; drug; efficient basket; basket ... See more keywords
A new basket trial design based on clustering of homogeneous subpopulations
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2021.1897993
Abstract: ABSTRACT As new findings in oncology suggest a focus on individualized and targeted therapies, the demand for adequate clinical trial designs rises, whereby the focus is mainly on early development phases (phase I and II).… read more here.
Keywords: trial; basket trial; trial design; oncology ... See more keywords
Biomarker-driven basket trial designs: origins and new methodological developments
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2024.2358806
Abstract: ABSTRACT Due to increased use of gene sequencing techniques, understanding of cancer on a molecular level has evolved, in terms of both diagnosis and evaluation in response to initial therapies. In parallel, clinical trials meant… read more here.
Keywords: basket; basket trial; driven basket; biomarker driven ... See more keywords
OA26 Characterisation of a basket trial population for arthritis associated with ANA-positive RMDs
Sign Up to like & getrecommendations! Published in 2023 at "Rheumatology"
DOI: 10.1093/rheumatology/kead104.026
Abstract: Musculoskeletal inflammation is the most common reason for the inclusion of patients in SLE trials or biologic use. It is also common across other ANA-associated diseases, but these patients do not have access to the… read more here.
Keywords: basket trial; inflammation; ana associated; arthritis ... See more keywords
A phase 2b basket trial approach to treat multiple rare and fibrotic skin diseases
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2025.1637040
Abstract: Fibrotic skin diseases are rare, chronic, and often debilitating conditions characterized by excessive extracellular matrix deposition, leading to tissue scarring and functional impairment. Despite their severity, diseases—such as lichen sclerosus et atrophicus (LSA), frontal fibrosing… read more here.
Keywords: skin diseases; rare fibrotic; trial; basket trial ... See more keywords