An efficient basket trial design.
Sign Up to like & getrecommendations! Published in 2017 at "Statistics in medicine"
DOI: 10.1002/sim.7227
Abstract: The landscape for early phase cancer clinical trials is changing dramatically because of the advent of targeted therapy. Increasingly, new drugs are designed to work against a target such as the presence of a specific… read more here.
Keywords: drug works; drug; efficient basket; basket ... See more keywords
A new basket trial design based on clustering of homogeneous subpopulations
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2021.1897993
Abstract: ABSTRACT As new findings in oncology suggest a focus on individualized and targeted therapies, the demand for adequate clinical trial designs rises, whereby the focus is mainly on early development phases (phase I and II).… read more here.
Keywords: trial; basket trial; trial design; oncology ... See more keywords
OA26 Characterisation of a basket trial population for arthritis associated with ANA-positive RMDs
Sign Up to like & getrecommendations! Published in 2023 at "Rheumatology"
DOI: 10.1093/rheumatology/kead104.026
Abstract: Musculoskeletal inflammation is the most common reason for the inclusion of patients in SLE trials or biologic use. It is also common across other ANA-associated diseases, but these patients do not have access to the… read more here.
Keywords: basket trial; inflammation; ana associated; arthritis ... See more keywords