Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa
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DOI: 10.1021/acs.jmedchem.2c01597
Abstract: We have developed compounds with a promising activity against Acinetobacter baumannii and Pseudomonas aeruginosa, which are both on the WHO priority list of antibiotic-resistant bacteria. Starting from DNA gyrase inhibitor 1, we identified compound 27,… read more here.
Keywords: activity acinetobacter; activity; acinetobacter baumannii; baumannii pseudomonas ... See more keywords
Occurrence and Diversity of Intra- and Interhospital Drug-Resistant and Biofilm-Forming Acinetobacter baumannii and Pseudomonas aeruginosa.
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DOI: 10.1089/mdr.2019.0214
Abstract: Acinetobacter baumannii and Pseudomonas aeruginosa are the most relevant Gram-negative bacteria associated with hospital and opportunistic infections. This study aimed to evaluate the dynamics of drug-resistant A. baumannii and P. aeruginosa and biofilm formers from… read more here.
Keywords: pseudomonas aeruginosa; drug; baumannii pseudomonas; drug resistant ... See more keywords
Activity of cefiderocol against high-risk clones of multidrug-resistant Enterobacterales, Acinetobacter baumannii, Pseudomonas aeruginosa and Stenotrophomonas maltophilia
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DOI: 10.1093/jac/dkaa117
Abstract: Abstract Background Cefiderocol is a novel siderophore cephalosporin, developed for activity against MDR Gram-negative bacilli (MDR-GNB). Objectives To assess the in vitro antibacterial activity of cefiderocol against a collection of MDR-GNB clinical isolates from hospitals… read more here.
Keywords: pseudomonas aeruginosa; activity cefiderocol; baumannii pseudomonas; cefiderocol ... See more keywords