Targeting BAX ubiquitin‐binding sites reveals that BAX activation is essential for its ubiquitin‐dependent degradation
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DOI: 10.1002/jcb.29505
Abstract: BAX is an important proapoptotic protein of the BCL‐2 family, and its stability is essential for the regulation of the mitochondrial apoptotic pathway. A previous study revealed that BAX could undergo degradation through the ubiquitin‐proteasome… read more here.
Keywords: bax; degradation; ubiquitin binding; binding sites ... See more keywords
Probing BAK and BAX Activation and Pore Assembly with Cytochrome c Release, Limited Proteolysis, and Oxidant-Induced Linkage.
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DOI: 10.1007/978-1-4939-8861-7_14
Abstract: Mitochondrial permeabilization is a key event in the intrinsic pathway of apoptosis, and is mediated by either of the BCL-2 family members BAK or BAX. These two proteins generate pores in the mitochondrial outer membrane… read more here.
Keywords: bax; probing bak; bak bax; bax activation ... See more keywords