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Published in 2017 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2017.03.011
Abstract: Aberrant apoptosis can lead to acute or chronic degenerative diseases. Mitochondrial outer membrane permeabilization (MOMP) triggered by the oligomerization of the Bcl-2 family proteins Bax/Bak is an irreversible step leading to execution of apoptosis. Here, we describe…
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Keywords:
bax;
oligomerization;
small molecule;
bax bak ... See more keywords
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Published in 2017 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2016.11.004
Abstract: Bax and its homolog Bak are key regulators of the mitochondrial pathway of apoptosis. On cell stress Bax and Bak accumulate at distinct foci on the mitochondrial surface where they undergo a conformational change, oligomerize,…
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Keywords:
pores closing;
closing circle;
bak pores;
bak ... See more keywords
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Published in 2019 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a036319
Abstract: The BCL-2 family of proteins control a key checkpoint in apoptosis, that of mitochondrial outer membrane permeabilization or, simply, mitochondrial poration. The family consists of three subgroups: BH3-only initiators that respond to apoptotic stimuli; antiapoptotic…
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Keywords:
bcl family;
bak bok;
family;
effector proteins ... See more keywords
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Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5731
Abstract: Many of the most effective anti-cancer therapies induce apoptosis in cancer cells by damaging DNA. Even when effective at eradicating primary cancers, DNA-damaging anti-cancer agents cause mutations that can lead to the development of secondary…
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Keywords:
bax bak;
cancer cells;
apoptosis;
cancer ... See more keywords
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Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.2582
Abstract: 2582Background: Clinical development of promising small molecule Mcl-1 inhibitors is underway. The Mcl-1 inhibitors act by disrupting complexes of Mcl-1 with pro-apoptotic proteins such as BAK/BIM/...
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Keywords:
mcl;
pharmacodynamic biomarker;
mcl inhibitors;
bak heterodimer ... See more keywords
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Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.958476
Abstract: Infectious spleen and kidney necrosis virus (ISKNV) infections can trigger host cell death and are correlated with viral replication; however, they have rarely been considered in terms of the host organelle involvement. In the present…
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Keywords:
cell death;
bax bak;
stress;
oxidative stress ... See more keywords