A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection.
Sign Up to like & getrecommendations! Published in 2017 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2017.03.011
Abstract: Aberrant apoptosis can lead to acute or chronic degenerative diseases. Mitochondrial outer membrane permeabilization (MOMP) triggered by the oligomerization of the Bcl-2 family proteins Bax/Bak is an irreversible step leading to execution of apoptosis. Here, we describe… read more here.
Keywords: bax; oligomerization; small molecule; bax bak ... See more keywords
Bax and Bak Pores: Are We Closing the Circle?
Sign Up to like & getrecommendations! Published in 2017 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2016.11.004
Abstract: Bax and its homolog Bak are key regulators of the mitochondrial pathway of apoptosis. On cell stress Bax and Bak accumulate at distinct foci on the mitochondrial surface where they undergo a conformational change, oligomerize,… read more here.
Keywords: pores closing; closing circle; bak pores; bak ... See more keywords
Lipid unsaturation promotes BAX and BAK pore activity during apoptosis
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-49067-6
Abstract: BAX and BAK are proapoptotic members of the BCL2 family that directly mediate mitochondrial outer membrane permeabilition (MOMP), a central step in apoptosis execution. However, the molecular architecture of the mitochondrial apoptotic pore remains a… read more here.
Keywords: bax bak; lipid unsaturation; apoptosis; pore activity ... See more keywords
BAX, BAK, and BOK: A Coming of Age for the BCL-2 Family Effector Proteins.
Sign Up to like & getrecommendations! Published in 2019 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a036319
Abstract: The BCL-2 family of proteins control a key checkpoint in apoptosis, that of mitochondrial outer membrane permeabilization or, simply, mitochondrial poration. The family consists of three subgroups: BH3-only initiators that respond to apoptotic stimuli; antiapoptotic… read more here.
Keywords: bcl family; bak bok; family; effector proteins ... See more keywords
Differential regulation of BAX and BAK apoptotic activity revealed by small molecules
Sign Up to like & getrecommendations! Published in 2025 at "Science Advances"
DOI: 10.1126/sciadv.adr8146
Abstract: Defective apoptosis mediated by B cell lymphoma 2 antagonist/killer (BAK) or B cell lymphoma 2–associated X protein (BAX) underlies various pathologies including autoimmune and degenerative conditions. On mitochondria, voltage-dependent anion channel 2 (VDAC2) interacts with… read more here.
Keywords: vdac2; bax bak; wehi 3773; bax ... See more keywords
Abstract 5731: Apoptosis Inducing Agent 1 enhances cancer therapy-induced apoptosis by direct interaction with BAX and BAK
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5731
Abstract: Many of the most effective anti-cancer therapies induce apoptosis in cancer cells by damaging DNA. Even when effective at eradicating primary cancers, DNA-damaging anti-cancer agents cause mutations that can lead to the development of secondary… read more here.
Keywords: bax bak; cancer cells; apoptosis; cancer ... See more keywords
Abstract A010: Proteasome inhibitors induce a BAX and BAK independent, non-canonical apoptosis
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1538-8514.synthleth24-a010
Abstract: In the intrinsic pathway of apoptosis, death stimuli (including drugs, cellular stress, viral infections, etc.) trigger the oligomerization of BAX and BAK resulting in pore formation in the outer mitochondrial membrane to release cytochrome c… read more here.
Keywords: bax bak; proteasome inhibitors; bak independent; non canonical ... See more keywords
BAX-BAK heterodimer as a pharmacodynamic biomarker of on-target drug action of Mcl-1 inhibitors to evaluate in-vivo effectiveness.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.2582
Abstract: 2582Background: Clinical development of promising small molecule Mcl-1 inhibitors is underway. The Mcl-1 inhibitors act by disrupting complexes of Mcl-1 with pro-apoptotic proteins such as BAK/BIM/... read more here.
Keywords: mcl; pharmacodynamic biomarker; mcl inhibitors; bak heterodimer ... See more keywords
Infectious spleen and kidney necrosis virus induces the reactive oxidative species/Nrf2-mediated oxidative stress response for the regulation of mitochondrion-mediated Bax/Bak cell death signals in GF-1 cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.958476
Abstract: Infectious spleen and kidney necrosis virus (ISKNV) infections can trigger host cell death and are correlated with viral replication; however, they have rarely been considered in terms of the host organelle involvement. In the present… read more here.
Keywords: cell death; bax bak; stress; oxidative stress ... See more keywords