Farnesol mitigates methotrexate-induced intestinal toxicity by enhancing SIRT1, PPAR-γ, and Nrf2 signaling and attenuating Bax/cytochrome c/caspase-3–mediated apoptosis
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DOI: 10.1080/08923973.2025.2585088
Abstract: Abstract Objectives The adherence to methotrexate (MTX) prolonged therapy in various cancers and autoimmune disorders is restricted due to its deleterious effects on several organs, like the liver, kidney, and intestine. Farnesol (FAR), a sesquiterpene… read more here.
Keywords: induced intestinal; ppar; farnesol; bax cytochrome ... See more keywords