Identification and expression analysis of alternatively spliced new transcript isoform of Bax gene in mouse.
Sign Up to like & getrecommendations! Published in 2017 at "Gene"
DOI: 10.1016/j.gene.2017.04.020
Abstract: Bax, a pro-apoptotic member of Bcl-2 family regulates apoptosis through homodimerization/heterodimerization with Bcl-2. Bax-α is the only product of the Bax gene that has been extensively studied. Bax-α exists in inactive form and several conformational… read more here.
Keywords: new transcript; transcript; transcript variant; bax gene ... See more keywords
Efficient CRISPR/Cas9-Mediated BAX Gene Ablation in CHO Cells To Impair Apoptosis and Enhance Recombinant Protein Production
Sign Up to like & getrecommendations! Published in 2023 at "Iranian Journal of Biotechnology"
DOI: 10.30498/ijb.2023.343428.3388
Abstract: Background: Despite recent advances in recombinant biotherapeutics production using CHO cells, their productivity remains lower than industrial needs, mainly due to apoptosis. Objectives: Present study aimed to exploit CRISPR/Cas9 technology to specifically disrupt the BAX… read more here.
Keywords: crispr cas9; apoptosis; production; bax gene ... See more keywords