Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels In Vivo.
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DOI: 10.1021/acs.jmedchem.9b01382
Abstract: The human luteinizing hormone receptor (hLH-R) is a member of the glycoprotein hormone family of GPCRs, activated by luteinizing hormone (hLH) and essentially involved in the regulation of sex hormone production. Thus, hLH-R represents a… read more here.
Keywords: hormone; bay 298; luteinizing hormone; bay ... See more keywords