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Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c02082
Abstract: Herein, we describe the identification, chemical optimization, and preclinical characterization of novel soluble guanylate cyclase (sGC) stimulators. Given the very broad therapeutic opportunities for sGC stimulators, new tailored molecules for distinct indications with specific pharmacokinetics,…
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Keywords:
sgc stimulators;
guanylate cyclase;
hypertension;
bay 747 ... See more keywords
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1
Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-07391-1
Abstract: Soluble guanylate cyclase (sGC) requires a heme-group bound in order to produce cGMP, a second messenger involved in memory formation, while heme-free sGC is inactive. Two compound classes can increase sGC activity: sGC stimulators acting…
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Keywords:
runcaciguat;
sgc;
memory;
bay 747 ... See more keywords