Articles with "bay 747" as a keyword



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New Generation of sGC Stimulators: Discovery of Imidazo[1,2-a]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Resistant Hypertension.

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Published in 2023 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.2c02082

Abstract: Herein, we describe the identification, chemical optimization, and preclinical characterization of novel soluble guanylate cyclase (sGC) stimulators. Given the very broad therapeutic opportunities for sGC stimulators, new tailored molecules for distinct indications with specific pharmacokinetics,… read more here.

Keywords: sgc stimulators; guanylate cyclase; hypertension; bay 747 ... See more keywords
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The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms

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Published in 2022 at "Scientific Reports"

DOI: 10.1038/s41598-022-07391-1

Abstract: Soluble guanylate cyclase (sGC) requires a heme-group bound in order to produce cGMP, a second messenger involved in memory formation, while heme-free sGC is inactive. Two compound classes can increase sGC activity: sGC stimulators acting… read more here.

Keywords: runcaciguat; sgc; memory; bay 747 ... See more keywords