Phosphodiesterase-2 inhibitor reverses post-traumatic stress induced fear memory deficits and behavioral changes via cAMP/cGMP pathway.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173768
Abstract: Phosphodiesterase 2 is one of the phosphodiesterase (PDEs) family members that regulate cyclic nucleotide (namely cAMP and cGMP) concentrations. The present study determined whether PDE2 inhibition could rescue post-traumatic stress disorder (PTSD)-like symptoms. Mice were… read more here.
Keywords: bay 7550; inhibitor; fear memory; phosphodiesterase ... See more keywords
The phosphodiesterase type 2 inhibitor BAY 60‐7550 reverses functional impairments induced by brain ischemia by decreasing hippocampal neurodegeneration and enhancing hippocampal neuronal plasticity
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.13461
Abstract: Cognitive and affective impairments are the most characterized consequences following cerebral ischemia. BAY 60‐7550, a selective phosphodiesterase type 2 inhibitor (PDE2‐I), presents memory‐enhancing and anxiolytic‐like properties. The behavioral effects of BAY 60‐7550 have been associated… read more here.
Keywords: neuronal plasticity; bay 7550; ischemia; brain ischemia ... See more keywords