Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01606
Abstract: The availability of a chemical probe to study the role of a specific domain of a protein in a concentration- and time-dependent manner is of high value. Herein, we report the identification of a highly… read more here.
Keywords: bay 885; probe; potent highly; characterization potent ... See more keywords
BAY-885, a mitogen-activated protein kinase kinase 5 inhibitor, induces apoptosis by regulating the endoplasmic reticulum stress/Mcl-1/Bim pathway in breast cancer cells
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DOI: 10.1080/21655979.2022.2078557
Abstract: ABSTRACT The mitogen-activated protein kinase kinase 5 (MEK5)/extracellular signal-regulated kinase 5 (ERK5) axis has been reported to promote tumorigenesis in breast cancer (BC). Therefore, targeting the MEK5/ERK5 axis is a potential strategy against BC. BAY-885… read more here.
Keywords: stress; mitogen activated; bim; kinase ... See more keywords
Abstract 5866: Discovery and profiling of a highly potent and selective ERK5 inhibitor: BAY-885
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DOI: 10.1158/1538-7445.am2018-5866
Abstract: ERK5 (Extracellular signal regulated kinase 5, also known as MAPK7, Gene ID: 5598) is a key integrator of cellular signal transduction and it has been shown to play a role in various cellular processes such… read more here.
Keywords: bay 885; highly potent; potent selective; inhibitor ... See more keywords