A practical Bayesian adaptive design incorporating data from historical controls.
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DOI: 10.1002/sim.7897
Abstract: In this paper, we develop the fixed-borrowing adaptive design, a Bayesian adaptive design which facilitates information borrowing from a historical trial using subject-level control data while assuring a reasonable upper bound on the maximum type… read more here.
Keywords: methodology; trial; analysis; bayesian adaptive ... See more keywords
Frequentist operating characteristics of Bayesian optimal designs via simulation.
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DOI: 10.1002/sim.8279
Abstract: Bayesian adaptive designs have become popular because of the possibility of increasing the number of patients treated with more beneficial treatments, while still providing sufficient evidence for treatment efficacy comparisons. It can be essential, for… read more here.
Keywords: frequentist; medicine; trial; power ... See more keywords
Optimizing interim analysis timing for Bayesian adaptive commensurate designs.
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DOI: 10.1002/sim.8414
Abstract: In developing products for rare diseases, statistical challenges arise due to the limited number of patients available for participation in drug trials and other clinical research. Bayesian adaptive clinical trial designs offer the possibility of… read more here.
Keywords: interim analysis; bayesian adaptive; optimizing interim; adaptive commensurate ... See more keywords
Bayesian adaptive testing with polytomous items
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DOI: 10.1007/s41237-020-00114-8
Abstract: An extremely efficient MCMC method for Bayesian adaptive testing with polytomous items is explained both conceptually and in mathematical detail. Results from extensive simulation studies with different item pools, polytomous response models, calibration sample sizes,… read more here.
Keywords: adaptive testing; polytomous items; bayesian adaptive; testing polytomous ... See more keywords
Inferring Atmospheric Release Characteristics in a Large Computer Experiment Using Bayesian Adaptive Splines
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DOI: 10.1080/01621459.2018.1562933
Abstract: Abstract An atmospheric release of hazardous material, whether accidental or intentional, can be catastrophic for those in the path of the plume. Predicting the path of a plume based on characteristics of the release (location,… read more here.
Keywords: adaptive splines; atmospheric release; using bayesian; release characteristics ... See more keywords
Bayesian adaptive bandwidth selector for multivariate discrete kernel estimator
Sign Up to like & getrecommendations! Published in 2018 at "Communications in Statistics - Theory and Methods"
DOI: 10.1080/03610926.2017.1346807
Abstract: ABSTRACT We treat a non parametric estimator for joint probability mass function, based on multivariate discrete associated kernels which are appropriated for multivariate count data of small and moderate sample sizes. Bayesian adaptive estimation of… read more here.
Keywords: multivariate discrete; adaptive bandwidth; estimator; selector multivariate ... See more keywords
A Bayesian adaptive design for cancer phase I trials using a flexible range of doses
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2017.1372774
Abstract: ABSTRACT We present a Bayesian adaptive design for dose finding in cancer phase I clinical trials. The goal is to estimate the maximum tolerated dose (MTD) after possible modification of the dose range during the… read more here.
Keywords: trial; range doses; bayesian adaptive; adaptive design ... See more keywords
A Bayesian adaptive design for clinical trials of rare efficacy outcomes with multiple definitions
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DOI: 10.1177/17407745221118366
Abstract: Introduction: Bayesian adaptive designs for clinical trials have gained popularity in the recent years due to the flexibility and efficiency that they offer. We consider the scenario where the outcome of interest comprises events with… read more here.
Keywords: clinical trials; adaptive design; bayesian adaptive; trials rare ... See more keywords
Over-accrual in Bayesian adaptive trials with continuous futility stopping.
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DOI: 10.1177/17407745231154685
Abstract: Background: We explore frequentist operating characteristics of a Bayesian adaptive design that allows continuous early stopping for futility. In particular, we focus on the power versus sample size relationship when more patients are accrued than… read more here.
Keywords: stopping futility; bayesian adaptive; futility; adaptive trials ... See more keywords
Bayesian adaptive trials for rare cardiovascular conditions.
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DOI: 10.2217/fca-2017-0040
Abstract: Escalating costs of cardiovascular trials are limiting medical innovations, prompting the development of more efficient and flexible study designs. The Bayesian paradigm offers a framework conducive to adaptive trial methodologies and is well suited for… read more here.
Keywords: cardiovascular conditions; study; bayesian adaptive; trials rare ... See more keywords