Bayesian order constrained adaptive design for phase II clinical trials evaluating subgroup-specific treatment effect.
Sign Up to like & getrecommendations! Published in 2023 at "Statistical methods in medical research"
DOI: 10.1177/09622802231158738
Abstract: The “one-size-fits-all’’ paradigm is inappropriate for phase II clinical trials evaluating biotherapies, which are often expected to have substantial heterogeneous treatment effects among different subgroups defined by biomarker. For these biotherapies, the objective of phase… read more here.
Keywords: adaptive design; bayesian order; design; constrained adaptive ... See more keywords