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Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200435
Abstract: Acylated Morita‐Baylis‐Hillman (MBH) adducts were synthesised and subjected to enzymatic kinetic resolution (EKR) by hydrolysis employing various lipase enzymes: from P. fluorescens, P. cepacia (PCL), C. antarctica A (CAL−A), C. antarctica B (CAL−B) and Novozyme…
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Keywords:
lipase;
morita baylis;
baylis hillman;
transesterification ... See more keywords
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Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.03.004
Abstract: The wide variety of potent biological activities of Morita-Baylis-Hillman adducts (MBH) encouraged us to synthesize new series of products belonging to this class of compounds, possessing different functionalities and exhibiting potential antioxidant activity. As part…
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Keywords:
antioxidant activity;
morita baylis;
potential antioxidant;
baylis hillman ... See more keywords
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Published in 2019 at "Comptes Rendus Chimie"
DOI: 10.1016/j.crci.2019.09.002
Abstract: Abstract New highly functionalized scaffolds, namely 2-(2-furyl)hydroxymethyl-2-cycloalkenones, are reported. The access to these systems is one step using an aqueous Morita–Baylis–Hillman reaction combining hydroxymethylfurfural and glucosyloxymethylfurfural and cycloalkenones for which the reaction conditions (promoter, solvent,…
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Keywords:
morita baylis;
baylis hillman;
hydroxymethylfurfural glucosyloxymethylfurfural;
functionalized scaffolds ... See more keywords
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Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2016.11.056
Abstract: Abstract Several alkynes and azides were prepared starting from betulinic acid and Baylis-Hillman reaction-derived allylic alcohols. These alkynes and azides were then coupled under click cycloaddition conditions to obtain functionalized betulinic acid-triazole conjugates. Similarly, pyrazinyl-…
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Keywords:
acid triazole;
baylis hillman;
betulinic acid;
acid ... See more keywords
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Published in 2021 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2020.152746
Abstract: Abstract The preparation of N-containing α,β-unsaturated carboxylate derivatives from α-silylamine and Baylis-Hillman adducts under visible light irradiation was reported. The formation of α-aminoalkyl radical is regioselective compared with the previous reports. The reaction was successfully…
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Keywords:
adducts visible;
baylis hillman;
visible light;
coupling reaction ... See more keywords
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Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01940
Abstract: The controlled release of a molecule of interest (MOI) is useful in probe design, prodrug construction, and drug delivery. We report herein a versatile thiol-triggered fluorogenic release system using the Baylis-Hillman (BH) adducts as a…
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Keywords:
baylis hillman;
fluorogenic release;
hillman adducts;
release system ... See more keywords
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Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c03689
Abstract: A cascade assembly between isatin-derived Morita-Baylis-Hillman carbonates and o-hydroxybenzylideneacetones has been developed under the relay catalysis of Pd(PPh3)4 and DBU, affording a spectrum of 1,2,3,4-tetrahydrodibenzo[b,d]furan architectures incorporating a spirooxindole motif in moderate to good yields…
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Keywords:
hillman carbonates;
relay catalysis;
morita baylis;
baylis hillman ... See more keywords
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Published in 2022 at "Organic Letters"
DOI: 10.1021/acs.orglett.2c01529
Abstract: Electrosynthesis is effectively employed in a general regio- and stereoselective alkylation of Morita–Baylis–Hillman compounds. The exposition of N-acyloxyphthalimides (redox-active esters) to galvanostatic electroreductive conditions, following the sacrificial-anode strategy, is proved an efficient and practical method…
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Keywords:
morita baylis;
regio stereoselective;
baylis hillman;
alkylation morita ... See more keywords
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Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b00834
Abstract: A phosphine-catalyzed [3 + 3] cyclization strategy between para-quinamines and HCHO Morita-Baylis-Hillman (MBH) carbonates was discovered, delivering a series of highly functionalized hydroquinoline derivatives in moderate to good yields and excellent diastereoselectivity. Moreover, mechanistic insights,…
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Keywords:
phosphine catalyzed;
morita baylis;
baylis hillman;
cyclization ... See more keywords
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Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b01783
Abstract: The phosphine-catalyzed tandem annulation reaction of Morita-Baylis-Hillman (MBH) alcohols with azomethine imines has been achieved for the synthesis of biologically important (epoxymethano)-pyrazolo[5,1- b]quinazoline derivatives. A variety of MBH alcohols and azomethine imines were well-tolerated under…
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Keywords:
morita baylis;
heterocyclic compounds;
baylis hillman;
direct activation ... See more keywords
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Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03823
Abstract: A weak carbonyl coordination-guided regioselective C4 allylation of indoles is demonstrated using the versatile Morita-Baylis-Hillman adduct in the presence of Rh catalysts in a redox-neutral fashion. The substrate scope, functional group diversity, oxidant free character,…
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Keywords:
morita baylis;
baylis hillman;
guided regioselective;
coordination guided ... See more keywords