Bazedoxifene increases the proliferation of human arterial endothelial cells but does not affect the expression of cyclins A, B, and D1 and of p27Kip1
Sign Up to like & getrecommendations! Published in 2021 at "Gynecological Endocrinology"
DOI: 10.1080/09513590.2021.1876653
Abstract: Abstract Objective Endothelial dysfunction and denudation are considered a first step in atherosclerosis. Endothelial proliferation is key for cellular repair. The effect of bazedoxifene on the vascular endothelium has not been explored. We investigated the… read more here.
Keywords: cyclins p27kip1; bazedoxifene; proliferation; bazedoxifene estradiol ... See more keywords
Bazedoxifene-induced vasodilation and inhibition of vasoconstriction is significantly greater than estradiol
Sign Up to like & getrecommendations! Published in 2019 at "Menopause"
DOI: 10.1097/gme.0000000000001195
Abstract: Objective: A new strategy for menopausal hormone therapy replaces medroxyprogesterone with the selective estrogen receptor modulator bazedoxifene. While the agonist or antagonist activity of bazedoxifene has been examined in other tissues, the current study explored… read more here.
Keywords: estrogen receptor; medroxyprogesterone estradiol; bazedoxifene; estradiol ... See more keywords
Bazedoxifene, a Postmenopausal Drug, Acts as an Antimalarial and Inhibits Hemozoin Formation
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DOI: 10.1128/spectrum.02781-21
Abstract: The emergence and spread of drug-resistant strains of the human malaria parasite Plasmodium falciparum has necessitated new drugs. Selective estrogen receptor modulators are in clinical use for the prevention and treatment of breast cancer and… read more here.
Keywords: estrogen receptor; plasmodium; hemozoin formation; drug ... See more keywords
Abstract 7302: Effect of estrogen receptor modulator bazedoxifene on progression of carcinogen induced bladder cancer in female F344 rats
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-7302
Abstract: Bladder Cancer (BC) is the second most common genitourinary cancer with high recurrence and mortality rate due to metastatic muscle invasive BC (MIBC). An estimated 82,290 adults in the United States will be diagnosed with… read more here.
Keywords: cancer; f344 rats; bazedoxifene; female f344 ... See more keywords
Bazedoxifene does not share estrogens effects on IgG sialylation
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DOI: 10.1371/journal.pone.0285755
Abstract: The incidence of rheumatoid arthritis (RA) increases at the same time as menopause when estrogen level decreases. Estrogen treatment is known to reduce the IgG pathogenicity by increasing the sialylation grade on the terminal glycan… read more here.
Keywords: igg sialylation; sialylation; estrogen treatment; bazedoxifene ... See more keywords
Effect of conjugated estrogens and bazedoxifene on glucose, energy and lipid metabolism in obese postmenopausal women.
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DOI: 10.1530/eje-20-0619
Abstract: OBJECTIVE Combining conjugated estrogens (CE) with the selective estrogen receptor modulator bazedoxifene (BZA) is a novel orally-administered menopausal therapy. We investigated the effect of CE/BZA on insulin sensitivity, energy metabolism, and serum metabolome in postmenopausal… read more here.
Keywords: conjugated estrogens; bazedoxifene; bza; effect ... See more keywords
Raloxifene and Bazedoxifene Could Be Promising Candidates for Preventing the COVID-19 Related Cytokine Storm, ARDS and Mortality
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DOI: 10.21873/invivo.12135
Abstract: The FDA-approved drugs raloxifene and bazedoxifene could be among the best candidates to prevent mortality in severe COVID-19 patients. Raloxifene and bazedoxifene inhibit IL-6 signaling at therapeutic doses, suggesting they have the potential to prevent… read more here.
Keywords: bazedoxifene; cytokine storm; bazedoxifene could; mortality ... See more keywords
Effect of bazedoxifene on expressions of VEGF, VEGFR2, COX-2 and inflammatory factors in a rat endometriosis model
Sign Up to like & getrecommendations! Published in 2021 at "Tropical Journal of Pharmaceutical Research"
DOI: 10.4314/tjpr.v18i9.2
Abstract: Purpose: To study the effect of bazedoxifene on the expressions of vascular endothelial growth factor (VEGF), soluble vascular endothelial growth factor receptor 2 (sVEGFR2), cyclooxygenase synthase 2 (COX-2) and inflammatory factors in a rat endometriosis… read more here.
Keywords: control group; bazedoxifene; control; group ... See more keywords