Microglia Regulate Blood–Brain Barrier Integrity via MiR‐126a‐5p/MMP9 Axis during Inflammatory Demyelination
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105442
Abstract: Blood–brain barrier (BBB) impairment is an early prevalent feature of multiple sclerosis (MS), and remains vital for MS progression. Microglial activation precedes BBB disruption and cellular infiltrates in the brain of MS patients. However, little… read more here.
Keywords: bbb; mir 126a; brain; integrity ... See more keywords
3D In Vitro Blood‐Brain‐Barrier Model for Investigating Barrier Insults
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DOI: 10.1002/advs.202205752
Abstract: The blood-brain-barrier (BBB) prevents that harmful substances in the blood enter the brain, and barrier disruption has been associated with a variety of central-nervous-system diseases. In vitro BBB models enable to recapitulate the BBB behavior… read more here.
Keywords: blood brain; bbb; barrier; brain barrier ... See more keywords
Activation of pial and dural macrophages and dendritic cells by cortical spreading depression
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Neurology"
DOI: 10.1002/ana.25169
Abstract: Cortical spreading depression (CSD) has long been implicated in migraine attacks with aura. The process by which CSD, a cortical event that occurs within the blood–brain barrier (BBB), results in nociceptor activation outside the BBB… read more here.
Keywords: activation pial; cortical spreading; spreading depression; bbb ... See more keywords
Phage display as a tool to discover blood–brain barrier (BBB)‐shuttle peptides: panning against a human BBB cellular model
Sign Up to like & getrecommendations! Published in 2017 at "Peptide Science"
DOI: 10.1002/bip.22928
Abstract: Most potential drugs for the treatment of central nervous system disorders do not cross the blood–brain barrier (BBB). Much research effort has been devoted to the discovery of new BBB‐shuttle peptides—most of which have been… read more here.
Keywords: bbb shuttle; phage display; bbb; model ... See more keywords
Microfluidic blood–brain barrier model provides in vivo‐like barrier properties for drug permeability screening
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26045
Abstract: Efficient delivery of therapeutics across the neuroprotective blood–brain barrier (BBB) remains a formidable challenge for central nervous system drug development. High‐fidelity in vitro models of the BBB could facilitate effective early screening of drug candidates… read more here.
Keywords: barrier; bbb; drug; permeability ... See more keywords
Unraveling In Vivo Brain Transport of Protein-Coated Fluorescent Nanodiamonds.
Sign Up to like & getrecommendations! Published in 2019 at "Small"
DOI: 10.1002/smll.201902992
Abstract: Nanotheranostics, combining diagnostics and therapy, has the potential to revolutionize treatment of neurological disorders. But one of the major obstacles for treating central nervous system diseases is the blood-brain barrier (BBB) preventing systemic delivery of… read more here.
Keywords: cell; bbb; vivo brain; transport ... See more keywords
Barrier Properties and Transcriptome Expression in Human iPSC‐Derived Models of the Blood–Brain Barrier
Sign Up to like & getrecommendations! Published in 2018 at "STEM CELLS"
DOI: 10.1002/stem.2908
Abstract: Cell‐based models of the blood–brain barrier (BBB) are important for increasing the knowledge of BBB formation, degradation and brain exposure of drug substances. Human models are preferred over animal models because of interspecies differences in… read more here.
Keywords: barrier; bbb; coculture; ipsc derived ... See more keywords
Transfection of primary brain capillary endothelial cells for protein synthesis and secretion of recombinant erythropoietin: a strategy to enable protein delivery to the brain
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2501-5
Abstract: Treatment of chronic disorders affecting the central nervous system (CNS) is complicated by the inability of drugs to cross the blood–brain barrier (BBB). Non-viral gene therapy applied to brain capillary endothelial cells (BCECs) denotes a… read more here.
Keywords: protein; secretion; transfection; bbb ... See more keywords
The cortical blood–brain barrier in multiple sclerosis: a gateway to progression?
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neurology"
DOI: 10.1007/s00415-017-8727-1
Abstract: Despite the historical focus on white matter pathology, it is now increasingly recognised that cortical tissue injury is critical to disease outcome. Cortical pathology occurs from the earliest disease stages, predominates in progressive MS, and… read more here.
Keywords: bbb; matter; disease; pathology ... See more keywords
Immortalised Hippocampal Astrocytes from 3xTG-AD Mice Fail to Support BBB Integrity In Vitro: Role of Extracellular Vesicles in Glial-Endothelial Communication
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-020-00871-w
Abstract: Impairments of the blood–brain barrier (BBB) and vascular dysfunction contribute to Alzheimer’s disease (AD) from the earliest stages. However, the influence of AD-affected astrocytes on the BBB remain largely unexplored. In the present study, we created… read more here.
Keywords: extracellular vesicles; bbb; astrocytes 3xtg; 3tg iastro ... See more keywords
Amyloid Beta 25–35 induces blood-brain barrier disruption in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-019-00447-8
Abstract: The amyloid β-peptide (Aβ) is transported across the blood-brain barrier (BBB) by binding with the receptor for advanced glycation end products (RAGE). Previously, we demonstrated that the Aβ fraction 25–35 (Aβ25–35) increases RAGE expression in… read more here.
Keywords: blood brain; disruption; bbb; vitro ... See more keywords