Neuroinflammation, oxidative stress, and blood-brain barrier (BBB) disruption in acute Utah electrode array implants and the effect of deferoxamine as an iron chelator on acute foreign body response.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.09.040
Abstract: The use of intracortical microelectrode arrays has gained significant attention in being able to help restore function in paralysis patients and study the brain in various neurological disorders. Electrode implantation in the cortex causes vasculature… read more here.
Keywords: array; disruption; bbb disruption; brain ... See more keywords
Physical blood‐brain barrier disruption induced by focused ultrasound does not overcome the transporter‐mediated efflux of erlotinib
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2018.11.009
Abstract: &NA; Overcoming the efflux mediated by ATP–binding cassette (ABC) transporters at the blood‐brain barrier (BBB) remains a challenge for the delivery of small molecule tyrosine kinase inhibitors (TKIs) such as erlotinib to the brain. Inhibition… read more here.
Keywords: disruption; fus; erlotinib; bbb disruption ... See more keywords
Inhibition of Na+-K+-2Cl− cotransporter attenuates blood-brain-barrier disruption in a mouse model of traumatic brain injury
Sign Up to like & getrecommendations! Published in 2017 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2017.05.020
Abstract: ABSTRACT Traumatic brain injury (TBI) can lead to long‐term motor and cognitive dysfunction, which can be at least partly attributed to blood‐brain barrier (BBB) disruption. The mechanisms underlying post‐TBI BBB disruption, however, are poorly understood… read more here.
Keywords: traumatic brain; disruption; inhibition; tbi ... See more keywords
Inhibition of serum and glucocorticoid regulated kinases by GSK650394 reduced infarct size in early cerebral ischemia-reperfusion with decreased BBB disruption
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2021.136143
Abstract: Blood-brain barrier (BBB) disruption is one of the most important pathological changes following cerebral ischemia-reperfusion. We tested whether inhibition of the serum and glucocorticoid regulated kinase 1 (SGK1) would decrease BBB disruption and contribute to… read more here.
Keywords: gsk650394; disruption; cerebral ischemia; ischemia reperfusion ... See more keywords
Zebularine protects against blood-brain-barrier (BBB) disruption through increasing the expression of zona occludens-1 (ZO-1) and vascular endothelial (VE)-cadherin
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2024323
Abstract: ABSTRACT Blood-brain-barrier (BBB) disruption is an important pathological characteristic of ischemic stroke (IS) and mainly results from dysfunction of brain vascular endothelial cells and tight junctions. Zebularine is a novel inhibitor of DNA methyltransferase (DNMT).… read more here.
Keywords: zebularine; vascular endothelial; bbb disruption; blood brain ... See more keywords
Atorvastatin attenuates surgery-induced BBB disruption and cognitive impairment partly by suppressing NF-κB pathway and NLRP3 inflammasome activation in aged mice.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biochimica et biophysica Sinica"
DOI: 10.1093/abbs/gmab022
Abstract: In clinic, perioperative neurocognitive disorder is becoming a common complication of surgery in old patients. Neuroinflammation and blood-brain barrier (BBB) disruption are important contributors for cognitive impairment. Atorvastatin, as a strong HMG-CoA reductase inhibitor, has… read more here.
Keywords: surgery; atorvastatin; surgery induced; cognitive impairment ... See more keywords
SCIDOT-31. DELAYED CONTRAST MRI FOR HIGH SENSITIVITY DEPICTION OF SUBTLE BBB DISRUPTION IN BRAIN PATHOLOGIES AND AS MEANS FOR MONITORING/DEVELOPING BBB DISRUPTION TECHNOLOGIES
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.1167
Abstract: Understanding the effects of BBB disrupting technologies on the neurovascular unit is important for safety and for optimal timing of therapeutic agents administration. We studied the effects of two novel BBB disrupting methods employing pulsed… read more here.
Keywords: contrast; disruption; treatment; subtle bbb ... See more keywords
Imaging correlates of the Blood Brain Barrier disruption in HIV associated neurocognitive disorder and therapeutic implications.
Sign Up to like & getrecommendations! Published in 2019 at "AIDS"
DOI: 10.1097/qad.0000000000002300
Abstract: OBJECTIVE We explored the role of Blood brain barrier (BBB) disruption in the pathogenesis of HAND in the context of fully suppressive cART using Dynamic contrast enhanced perfusion (DCE-P) MRI. DCE-P is a new MRI… read more here.
Keywords: blood; hand; bbb disruption; disruption ... See more keywords
Transcellular routes of blood–brain barrier disruption
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Biology and Medicine"
DOI: 10.1177/15353702221080745
Abstract: Disruption of the blood–brain barrier (BBB) can occur through different mechanisms and pathways. As these pathways result in increased permeability to different classes of substances, it is likely that the neurological insults that occur will… read more here.
Keywords: bbb disruption; blood brain; brain barrier; disruption ... See more keywords
Aggf1 attenuates neuroinflammation and BBB disruption via PI3K/Akt/NF-κB pathway after subarachnoid hemorrhage in rats
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-018-1211-8
Abstract: BackgroundNeuroinflammation and blood-brain barrier (BBB) disruption are two critical mechanisms of subarachnoid hemorrhage (SAH)-induced brain injury, which are closely related to patient prognosis. Recently, angiogenic factor with G-patch and FHA domain 1 (Aggf1) was shown… read more here.
Keywords: aggf1; bbb disruption; pi3k akt; sah ... See more keywords
NDP-MSH binding melanocortin-1 receptor ameliorates neuroinflammation and BBB disruption through CREB/Nr4a1/NF-κB pathway after intracerebral hemorrhage in mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-019-1591-4
Abstract: BackgroundNeuroinflammation and blood-brain barrier (BBB) disruption are two vital mechanisms of secondary brain injury following intracerebral hemorrhage (ICH). Recently, melanocortin-1 receptor (Mc1r) activation by Nle4-D-Phe7-α-MSH (NDP-MSH) was shown to play a neuroprotective role in an… read more here.
Keywords: mc1r; bbb disruption; ndp msh; neuroinflammation bbb ... See more keywords