Tuning Properties for Blood-Brain Barrier (BBB) Permeation: A Statistics-Based Analysis.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00541
Abstract: In the effort to define a set of rules useful in tuning the properties for a successful BBB permeation, we statistically analyzed a set of 338 compounds and correlated their experimental in vivo logBB with… read more here.
Keywords: permeation; tuning properties; bbb bbb; bbb permeation ... See more keywords
Computerassisted models for Blood Brain Barrier permeation of 1, 5-Benzodiazepines.
Sign Up to like & getrecommendations! Published in 2020 at "Current computer-aided drug design"
DOI: 10.2174/1573409916666200131114018
Abstract: AIM To generate and validate predictive models for blood brain permeation (BBB) of CNS molecules using QSPR approach. BACKGROUND Prediction of molecules crossing BBB remain a challenge in drug delivery. Predictive models are designed for… read more here.
Keywords: blood brain; permeation; models blood; permeation benzodiazepines ... See more keywords