The Therapeutic Potential of Berberine in Lung Cancer
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DOI: 10.1002/ardp.70013
Abstract: Lung cancer has the second‐highest incidence rate after breast cancer and remains the leading cause of cancer‐related mortality. The 1‐year survival rate for lung cancer patients is below 50%, highlighting the urgent need for novel… read more here.
Keywords: cancer; lung cancer; therapeutic potential; bbr ... See more keywords
Berberine Enhances the Sensitivity of Colorectal Cancer Cells to 5‐FU Through Smoothing Endoplasmic Reticulum Stress‐Mediated Autophagic Flux
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DOI: 10.1002/cbin.70038
Abstract: Berberine (BBR), one of the main active isoquinoline alkaloids in Coptis chinensis, has gradually gained attention for its therapeutic effect on various tumors, including colorectal cancer (CRC). However, the detailed mechanisms underlying remain to be… read more here.
Keywords: colorectal cancer; autophagic flux; stress; endoplasmic reticulum ... See more keywords
Berberine combined with stachyose induces better glycometabolism than berberine alone through modulating gut microbiota and fecal metabolomics in diabetic mice
Sign Up to like & getrecommendations! Published in 2019 at "Phytotherapy Research"
DOI: 10.1002/ptr.6588
Abstract: Berberine (BBR), a small alkaloid, is used as a hypoglycemic agent in China. Stachyose (Sta), a Rehmannia glutinosa oligosaccharide, acts as a prebiotic. This study aimed to evaluate whether BBR combined with Sta produced better… read more here.
Keywords: sta; better glycometabolism; bbr; treatment ... See more keywords
Berberine Ameliorates MCAO Induced Cerebral Ischemia/Reperfusion Injury via Activation of the BDNF–TrkB–PI3K/Akt Signaling Pathway
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2472-4
Abstract: Cerebral ischemic injury remains associated with high mortality rates and lacks effective therapeutic intervention. Berberine (BBR) possesses anti-oxidant, anti-inflammatory, and anti-tumor activities, as well as potent neuroprotective effects. Although recent studies have examined the neuroprotective… read more here.
Keywords: injury; pi3k; bdnf trkb; bbr ... See more keywords
Berberine exerts neuroprotective activities against cerebral ischemia/reperfusion injury through up-regulating PPAR-γ to suppress NF-κB-mediated pyroptosis
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2021.09.005
Abstract: OBJECTIVE Berberine (BBR) is an anti-inflammatory alkaloid compound extracted from herbs. The purpose of this study is to probe the possible effect and the mechanism of BBR against cerebral ischemia/reperfusion (I/R) injury. METHODS In vitro… read more here.
Keywords: bbr; pyroptosis; cerebral ischemia; ischemia reperfusion ... See more keywords
Berberine improves intestinal barrier function and reduces inflammation, immunosuppression, and oxidative stress by regulating the NF-κB/MAPK signaling pathway in deoxynivalenol-challenged piglets.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental pollution"
DOI: 10.1016/j.envpol.2021.117865
Abstract: The aim of this study was to evaluate the effect of berberine (BBR) on the intestinal health of piglets exposed to deoxynivalenol (DON). A total of 180 weaned piglets were randomly allotted to 1 of… read more here.
Keywords: bbr; challenged piglets; regulating mapk; stress regulating ... See more keywords
Pharmacokinetics, excretion of 8‐cetylberberine and its main metabolites in rat urine
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2016.09.022
Abstract: Graphical abstract Figure. No Caption available. HighlightsThe pharmacokinetics of BBR and its derivatives including 8‐cetylberberine (8‐BBR‐C16) in rat plasma was studied by high performance liquid chromatography (HPLC).The excretion of 8‐BBR‐C16 in rat urine and feces… read more here.
Keywords: bbr; bbr c16; rat urine; main metabolites ... See more keywords
Berberine regulates macrophage polarization through IL-4-STAT6 signaling pathway in Helicobacter pylori-induced chronic atrophic gastritis.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118903
Abstract: AIMS We will investigate the anti-inflammatory activities of berberine (BBR) in treating chronic atrophic gastritis (CAG) induced by Helicobacter pylori (H. pylori). Furthermore, the underlying molecular mechanisms of BBR also will be explored systematically. MATERIALS… read more here.
Keywords: anti inflammatory; bbr; polarization; signaling pathway ... See more keywords
Berberine ameliorates doxorubicin-induced cognitive impairment (chemo brain) in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119078
Abstract: AIMS Cognitive decline is one of the most challenging issues for cancer survivors undergoing doxorubicin (DOX) based chemotherapy. Oxidative stress and inflammation primarily through tumor necrosis factor-alpha (TNF-α) are considered the key contributors to DOX-induced… read more here.
Keywords: dox induced; bbr; induced cognitive; cognitive impairment ... See more keywords
Improved motion correction of submillimetre 7T fMRI time series with Boundary-Based Registration (BBR)
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DOI: 10.1016/j.neuroimage.2020.116542
Abstract: Ultra-high field functional magnetic resonance imaging (fMRI) has allowed us to acquire images with submillimetre voxels. However, in order to interpret the data clearly, we need to accurately correct head motion and the resultant distortions.… read more here.
Keywords: motion; bbr; registration bbr; boundary based ... See more keywords
Involvement of AMP-activated protein kinase and Death Receptor 5 in TRAIL-Berberine-induced apoptosis of cancer cells
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DOI: 10.1038/s41598-018-23780-x
Abstract: Our previous studies indicated that combination of Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and PPARγ ligand Troglitazone (TZD), can induce significant apoptosis in various TRAIL-resistant prostate and hepatocellular carcinoma (HCC) cells. These also suggested serine/threonine… read more here.
Keywords: bbr; apoptosis; trail; kinase ... See more keywords